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SKOR1蛋白抗體

英文名稱 SKOR1
中文名稱 SKOR1蛋白抗體
別    名 AV273001; C230094B15Rik; Corepressor for LBX1; CORL1; Functional smad suppressing element 15; Functional Smad suppressing element on chromosome 15; Functional Smad-suppressing element on chromosome 15; Fussel-15; FUSSEL15; Ladybird homeobox corepressor 1; Lbx1 corepressor 1; LBXCOR1; Lbxcor1 homolog; SKI family transcriptional corepressor 1; Skor1; SKOR1_HUMAN; Transcriptional corepressor CORL1.
 
說 明 書 0.2ml  
研究領(lǐng)域 發(fā)育生物學(xué)  神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse SKOR1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
LBXCOR1 is a 965 amino acid protein belonging to the SKI family. Localizing to nucleus, LBXCOR1 is highly expressed in the central nervous system (CNS) as well as developing spinal cord and adult brain and testis. LBXCOR1 contains a CH1 domain which is required for transcriptional repression and also acts as a transcriptional co-repressor of LBX1. LBXCOR1 additionally interacts with SMAD1, SMAD2 and SMAD3, and inhibits BMP signaling. Existing as three alternatively spliced isoforms, the gene encoding LBXCOR1 maps to human chromosome 15q23. Encoding more than 700 genes, chromosome 15 is made up of approximay 106 million base pairs and consists of about 3% of the human genome. Angelman and Prader-Willi syndromes, as well as Tay-Sachs disease and Marfan syndorme, are all associated with mutations to chromosome 15.

Function:
Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.

Subcellular Location:
Nucleus.

Tissue Specificity:
Present specifically in cerebellar Purkinje cells (at protein level).

Similarity:
Belongs to the SKI family.

Database links:

Entrez Gene: 207667 Mouse

Entrez Gene: 315748 Rat

SwissProt: Q8BX46 Mouse

SwissProt: P84551 Rat

Unigene: 36349 Mouse

Unigene: 447200 Mouse

Unigene: 58197 Rat

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