ATP依賴的解旋酶SKIV2L2抗體 返回列表頁

ATP依賴的解旋酶SKIV2L2抗體

英文名稱 SKIV2L2
中文名稱 ATP依賴的解旋酶SKIV2L2抗體
別    名 2610528A15Rik; ATP dependent helicase SKIV2L2; Dob1; SK2L2_HUMAN; KIAA0052; MGC142069; mKIAA0052; Mtr4; superkiller viralicidic activity 2 like 2 (S. cerevisiae); Superkiller viralicidic activity 2 like 2.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SKIV2L2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SKIV2L2, or superkiller viralicidic activity 2 like 2, may be involved in pre-mRNA splicing. SKIV2L2 is an exosome-associated protein and may be involved in the recruitment of the exosome to pre-rRNA, to mediate the 3' end processing of 5.8S rRNA.

Function:
May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA.

Subunit:
Component of a TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex.

Subcellular Location:
Nucleus, nucleoplasm. Nucleus, nucleolus.

Similarity:
Belongs to the helicase family. SKI2 subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain. 

Gene ID:
23517

Database links:

Entrez Gene: 23517 Human

Entrez Gene: 72198 Mouse

SwissProt: P42285 Human

SwissProt: Q9CZU3 Mouse

Unigene: 274531 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-5171R    phospho-ATF2 (Ser94)磷酸化活化復(fù)制因子2抗體
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