精子頂體膜相關(guān)蛋白3抗體 返回列表頁

精子頂體膜相關(guān)蛋白3抗體

英文名稱 SPACA3
中文名稱 精子頂體膜相關(guān)蛋白3抗體
別    名 1700025M08Rik; ALLP17; Cancer/testis antigen 54; sperm acrosome associated 3; CT54; LYC3; Lysozyme like sperm specific secretory protein ALLP17; Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17; Lysozyme-like protein 3; LYZL3; processed form; SACA3_HUMAN; SLLP1; SPACA3; Sperm acrosome associated 3; Sperm acrosome membrane-associated protein 3; Sperm lysozyme-like protein 1; Sperm protein reactive with antisperm antibodies; Sperm protein reactive with ASA; 1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細胞生物  發(fā)育生物學  信號轉(zhuǎn)導  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
細胞定位 細胞膜 細胞外基質(zhì) 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPACA3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SPACA3 is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms; SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein.

Function:
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

Subcellular Location:
Secreted and Cytoplasmic vesicle > secretory vesicle > acrosome membrane. Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction.

Tissue Specificity:
The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta.

Post-translational modifications:
The processed form derives from the membrane form by proteolytic processing.xy-11805R    ATBF1α增強子結(jié)合蛋白1抗體
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