精子發(fā)生相關(guān)蛋白20抗體 返回列表頁(yè)

精子發(fā)生相關(guān)蛋白20抗體

英文名稱 SPATA20
中文名稱 精子發(fā)生相關(guān)蛋白20抗體
別    名 SPATA20; Sperm protein SSP411; Sperm-specific protein 411; Spermatogenesis associated 20; Spermatogenesis-associated protein 20; SPT20_HUMAN; Ssp411; Tisp78; Transcript increased in spermiogenesis 78.

說(shuō) 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  干細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, Cat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 58kDa
細(xì)胞定位 細(xì)胞外基質(zhì) 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPATA20
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SPATA20 is a 786 amino acid protein that may be involved in fertility regulation. SPATA20 is expressed in testis in an age dependent manner and localizes to round and elongated spermatids. SPATA20 contains a conserved thioredoxin-like domain near the N-terminus region and exists as four isoforms produced by alternative splicing events. SPATA20 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. 

Function:
May play a role in fertility regulation.

Subcellular Location:
Secreted.

Database links:

Entrez Gene: 511363 Cow

Entrez Gene: 491082 Dog

Entrez Gene: 100714104 Guinea pig

Entrez Gene: 100069987 Horse

Entrez Gene: 64847 Human

Entrez Gene: 217116 Mouse

Entrez Gene: 100286812 Pig

Entrez Gene: 360604 Rat

Omim: 613939 Human

SwissProt: Q8TB22 Human

SwissProt: Q80YT5 Mouse

SwissProt: Q6T393 Rat

Unigene: 103147 Human

Important Note:
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