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SHQ1蛋白抗體

英文名稱 SHQ1
中文名稱 SHQ1蛋白抗體
別    名 FLJ10539; Protein SHQ1 homolog; shq1; SHQ1 homolog (S. cerevisiae); SHQ1 homolog; SHQ1, H/ACA ribonucleoprotein assembly factor; SHQ1_HUMAN; Shq1p.

說 明 書 0.2ml  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SHQ1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of omerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]

Function:
Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including omerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with 0, NHP2, and NAF1 at the nascent H/ACA RNA.

Subcellular Location:
Cytoplasm > cytosol. Nucleus > nucleoplasm. May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites.

Similarity:
Belongs to the SHQ1 family.
Contains 1 CS domain.

Database links:

Entrez Gene: 55164 Human

Entrez Gene: 72171 Mouse

Omim: 613663 Human

SwissProt: Q6PI26 Human

SwissProt: Q7TMX5 Mouse

Unigene: 606584 Human

Unigene: 256022 Mouse

Important Note:
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