SHROOM4蛋白抗體 返回列表頁

SHROOM4蛋白抗體

英文名稱 SHROOM4
中文名稱 SHROOM4蛋白抗體
別    名 Protein Shroom4; RP11-119E20.1; Second homolog of apical protein; SHAP; SHRM4_HUMAN; Shroom family member 4; SHROOM4.
 
說 明 書 0.2ml  
研究領(lǐng)域 細胞生物  發(fā)育生物學  信號轉(zhuǎn)導  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SHROOM4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the
PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the APX/Shroom family, which contain an N-terminal PDZ domain and a C-terminal ASD2 motif. The encoded protein may play a role in cytoskeletal architecture. Mutations in this gene have been linked to Stocco dos Santos X-linked mental retardation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Function:
Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II.

Subcellular Location:
Cytoplasm > cytoskeleton. Shows partial colocalization with the cytoplasmic pool of F-actin.

Tissue Specificity:
Expressed in all fetal and adult tissues investigated. Expressed in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. In brain regions detected in cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe and putamen. The expression is strongest in the medulla and weakest in the cerebral cortex.

DISEASE:
Defects in SHROOM4 are the cause of mental retardation syndromic X-linked Stocco dos Santos type (SDSX) [MIM:300434]. A syndrome characterized by severe mental retardation with hyperactivity, aggressive behavior, delayed or no speech, and seizures. Additional features include congenital bilateral hip luxation, short stature, and kyphosis. Note=A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;8)(p11.22;p23.3) with FBXO25.
Note=A chromosomal aberration involving SHROOM4 is a cause of X-linked mental retardation (XLMR). Translocation t(X;19).

Similarity:
Belongs to the Shroom family.
Contains 1 ASD2 domain.
Contains 1 PDZ (DHR) domain.

Database links:

Entrez Gene: 57477 Human

Omim: 300579 Human

SwissProt: Q9ULL8 Human

Unigene: 420541 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-6521R    CRISP3富含半胱氨酸分泌蛋白3抗體
xy-6524R    CT26腫瘤/睪丸抗原26抗體
xy-4270R    CDKN2C細胞周期蛋白依賴性激酶抑制劑2C抗體
xy-4209R    Cullin 2Cullin2抗體
xy-6225R    CAMK1D鈣調(diào)蛋白激酶CaMK1D抗體
xy-6621R    CHX10CHX10蛋白抗體
xym-2141M    CRIPTO畸胎瘤衍化生長因子單克隆抗體(C端)
xy-4269R    CDKN2B細胞周期蛋白依賴性激酶抑制劑2B抗體
xym-2313M    CRIPTO畸胎瘤衍化生長因子單克隆抗體
xy-4272R    CHFR泛素連接酶蛋白CHFR抗體
xy-4208R    Cullin 1Cullin1抗體
xy-6598R    Cofilin肌動蛋白結(jié)合蛋白CFL抗體
xy-6580R    CDMP1軟骨衍生形態(tài)發(fā)生蛋白1抗體
xy-10032R    Beta-caseinβ-酪蛋白抗體
xy-15121R    c21orf63 21號染色體開放閱讀框63抗體
xy-15196R    C4orf524號染色體開放閱讀框52抗體
xy-15193R    C4orf404號染色體開放閱讀框40抗體
xy-4211R    Cullin 3Cullin3抗體
xy-4295R    CDC40細胞分裂周期同源蛋白40抗體
xy-5711R    CCDC106卷曲螺旋結(jié)構(gòu)域蛋白106抗體
xy-4207R    CHMP1A染色質(zhì)修飾蛋白1A抗體
xy-4516R    CPN10葉綠體伴侶蛋白抗體（蘋果）
xy-7783R    CDC20B細胞分裂周期蛋白20B抗體
xy-7755R    Cell division control protein septin D1細胞周期調(diào)控蛋白D1抗體
xy-7784R    ccnb1ip1周期蛋白B1結(jié)合蛋白1抗體
xy-8614R    Cdc14A細胞周期調(diào)控因子14A抗體
xy-9403R    C7orf12第七號染色體開放閱讀框12抗體
xy-8244R    CA XI碳酸酐酶11抗體
xy-8245R    Alpha caseinα酪蛋白抗體
xy-6905R    CDCREL細胞周期調(diào)控相關(guān)蛋白1
xy-6326R    ICAM1細胞間粘附分子1抗體