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SBDS蛋白抗體

英文名稱 SBDS
中文名稱 SBDS蛋白抗體
別    名 Shwachman Bodian-Diamond syndrome; 4733401P19Rik; AI836084; CGI 97; CGI-97; FLJ10917; MGC105922; Protein 22A3; Ribosome maturation protein SBDS; sbds; SBDS_HUMAN; SDS; Shwachman Bodian Diamond syndrome protein; Shwachman Bodian Diamond syndrome protein homolog; Shwachman-Bodian-Diamond syndrome protein; SWDS

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞周期蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SBDS
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jul 2008]

Function:
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.

Subcellular Location:
Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle. Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase.

Tissue Specificity:
Widely expressed.xy-6323R    CD105CD105抗體
xy-11453R    CNTN5軸突蛋白5抗體
xy-11454R    COUP-TF1轉(zhuǎn)錄因子COUP1抗體
xy-11460R    CELSR3表皮生長(zhǎng)因子樣蛋白1抗體
xy-4896R    CD66a癌胚抗原相關(guān)細(xì)胞粘附分子1抗體
xy-13797R    C19orf7519號(hào)染色體開放閱讀框75抗體
xy-11441R    Cryptochrome 1隱花色素蛋白1抗體
xy-11447R    CRY2隱花色素蛋白2抗體
xy-11981R    CACNA2鈣通道L型α2多肽抗體
xy-11982R    CACNB3L型電壓依賴型鈣通道β3(L-type Ca++ CPβ3)抗體
xy-11983R    CACNB4L型電壓依賴型鈣通道β4抗體
xy-11984R    CACNA1G + CACNA1H電壓依賴性鈣通道CACNA1G+CACNA1H抗體
xy-11986R    CABP1鈣結(jié)合蛋白1抗體
xy-11987R    CAPON神經(jīng)型一氧化氮合成酶結(jié)合蛋白抗體
xy-11998R    CHRM4毒蕈堿型乙酰膽堿受體M4抗體
xy-0771R    CaMK2 alpha鈣/鈣調(diào)素依賴蛋白激酶2α抗體
xy-11975R    CACYBP周期蛋白結(jié)合蛋白抗體
xy-7786R    CDCA2細(xì)胞分裂周期蛋白2抗體
xy-7785R    CDC45L細(xì)胞分裂周期調(diào)控蛋白45抗體
xy-7780R    CAPH染色體相關(guān)蛋白H抗體
xy-7788R    CEP76中心體蛋白質(zhì)76抗體
xy-7787R    CEP152中心體蛋白152抗體
xy-12425R    Casein kinase 1 gamma 2酪蛋白激酶1γ2/casein kinase Iγ1抗體
xy-8018R    CLPTM1唇裂和腭裂相關(guān)跨膜蛋白1抗體
xy-8024R    CKLFH8趨化素樣因子超家族成員8抗體
xy-8020R    CKLFH1趨化素樣因子超家族成員1抗體
xy-8017R    CLN6神經(jīng)細(xì)胞蠟樣質(zhì)脂褐質(zhì)沉積病蛋白CLN6抗體
xy-12005R    CEP104甘氨酸結(jié)合蛋白抗體
xy-11719R    Calcyon多巴胺D1受體相互作用蛋白抗體
xy-11721R    CapicuaCapicua蛋白抗體
xy-7983R    CA6碳酸酐酶6抗體
xy-8631R    Connexin 29間隙連接蛋白29抗體
xy-8697R    Connexin-29間隙連接蛋白29抗體
xy-4897R    CXCR7細(xì)胞表面趨化因子受體7抗體
xy-11711R    C1orf76神經(jīng)母細(xì)胞瘤源性分泌蛋白抗體
xy-11712R    CHMP2B染色質(zhì)修飾蛋白2B抗體
xy-11713R    CKAP1細(xì)胞骨架相關(guān)蛋白1/微管蛋白折疊輔助因子B抗體
xy-11714R    CLN5神經(jīng)細(xì)胞蠟樣質(zhì)脂褐質(zhì)沉積病蛋白CLN5抗體
xy-11715R    CLN8神經(jīng)細(xì)胞蠟樣質(zhì)脂褐質(zhì)沉積病蛋白CLN8抗體
xy-11716R    CRBNcereblon蛋白抗體
xy-11717R    CTRP5補(bǔ)體C1q和腫瘤壞死因子相關(guān)蛋白5抗體
xy-11718R    CUG-BP1胞苷尿苷鳥苷結(jié)合蛋白1抗體
xy-11831R    Chordin原腸胚雙向形成相關(guān)蛋白抗體