唾液酸結(jié)合性免疫球蛋白樣凝集素12抗體 返回列表頁

唾液酸結(jié)合性免疫球蛋白樣凝集素12抗體

英文名稱 SIGLECL1
中文名稱 唾液酸結(jié)合性免疫球蛋白樣凝集素12抗體
別    名 FLJ38600; S2V; sialic acid binding Ig-like lectin 12 (gene/pseudogene); Sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin-like 1; Sialic acid-binding immunoglobulin-like lectins; SIG12_HUMAN; Siglec-12; Siglec-L1; SIGLEC-like 1; SIGLEC-like gene; SIGLEC-like protein 1; Siglec-XII; Siglec12; SLG.
  
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIGLECL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular Location:
Membrane.

Tissue Specificity:
Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.

Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.xy-10144R    CD35Ⅰ型補(bǔ)體受體抗體（C3b/C4b受體抗體）
xy-10183R    CMKLR1趨化樣因子受體1抗體
xy-10185R    CMKLR1趨化樣因子受體1抗體
xy-12583R    phospho-beta Catenin (Ser33)磷酸化β-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-12854R    phospho-beta Catenin (Ser37)磷酸化β-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-12855R    phospho-beta Catenin (Thr41)磷酸化β-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-12856R    phospho-beta Catenin (Tyr333)磷酸化β-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-12857R    phospho-beta Catenin (Tyr489)磷酸化β-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-12858R    phospho-beta Catenin (Tyr86)磷酸化β-連環(huán)蛋白/β-連環(huán)素/β鏈接素抗體
xy-12859R    beta Crystallin A3βA3/A1-crystallin蛋白抗體
xy-12860R    Beta crystallin SγS-crystallin蛋白抗體
xy-15078R    C1orf851號染色體開放閱讀框85抗體
xy-15080R    C1orf871號染色體開放閱讀框87抗體
xy-15081R    C1ORF951號染色體開放閱讀框95抗體
xy-15088R    C1s 補(bǔ)體C1S鏈多肽抗體
xy-15089R    C20orf10620號染色體開放閱讀框106抗體
xy-15090R    C20orf10720號染色體開放閱讀框107抗體
xy-15091R    C20orf11720號染色體開放閱讀框117抗體
xy-15092R    C20orf11820號染色體開放閱讀框118抗體
xy-15095R    C20ORF14420號染色體開放閱讀框144抗體
xy-15096R    C20orf15120號染色體開放閱讀框151抗體
xy-15117R    c20orf7820號染色體開放閱讀框78抗體
xy-15103R    C20orf18720號染色體開放閱讀框187抗體
xy-15126R    C21orf5921號染色體開放閱讀框59抗體
xy-15097R    C20orf152 20號染色體開放閱讀框152抗體
xy-15098R    C20orf16520號染色體開放閱讀框165抗體
xy-15099R    C20orf16620號染色體開放閱讀框166抗體
xy-15100R    C20orf17320號染色體開放閱讀框173抗體
xy-15106R    C20orf2420號染色體開放閱讀框24抗體