絲氨酸/蘇氨酸蛋白激酶SIK3抗體 返回列表頁(yè)

絲氨酸/蘇氨酸蛋白激酶SIK3抗體

英文名稱(chēng) SIK3
中文名稱(chēng) 絲氨酸/蘇氨酸蛋白激酶SIK3抗體
別    名 FLJ12240; KIAA0999; L19; QSK; Salt inducible kinase 3; serine/threonine-protein kinase QSK; Serine/threonine-protein kinase SIK3; SIK 3; SIK family kinase 3; SIK3_HUMAN.

說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 140kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIK3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimay involved in this process are the serine/threonine (Ser/Thr) protein kinases. The salt-inducible kinases (SIKs) are a family of related serine-threonine kinases and are key enzymes that modulate important processes such as steroid hormone biosynthesis and insulin signaling in adipocytes. QSK, also known as L19 or SIK3 (salt-inducible kinase 3), is a 1,263 amino acid cytoplasmic protein belonging to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and the AMPK subfamily. Ubiquitously expressed, QSK consists of one protein kinase domain and a UBA domain. QSK is activated by 14-3-3 Ω and utilizes magnesium as a cofactor. QSK exists as three alternatively spliced isoforms.

Function:
Activated by phosphorylation on Thr 163 by STK11 in complex with STE20 related adapter alpha (STRAD alpha) pseudo kinase and CAB39. Binds to and is activated by YWHAZ when phosphorylated on Thr 163.

Subcellular Location:
Cytoplasm

Database links:

Entrez Gene: 23387 Human

Entrez Gene: 70661 Mouse

Omim: 614776 Human

SwissProt: Q9Y2K2 Human

SwissProt: Q6P4S6 Mouse

Unigene: 167451 Human

Unigene: 219459 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xy-15109R    C20orf30 20號(hào)染色體開(kāi)放閱讀框30抗體
xy-15111R    C20orf420號(hào)染色體開(kāi)放閱讀框4抗體
xy-15113R    C20orf720號(hào)染色體開(kāi)放閱讀框7抗體
xy-15118R    C20orf79 20號(hào)染色體開(kāi)放閱讀框79抗體
xy-15119R    C20orf9420號(hào)染色體開(kāi)放閱讀框94抗體
xy-15125R    C21orf3721號(hào)染色體開(kāi)放閱讀框37抗體
xy-15132R    C22orf15 22號(hào)染色體開(kāi)放閱讀框15抗體
xy-15131R    C22orf1322號(hào)染色體開(kāi)放閱讀框13抗體
xy-15134R    C22orf2622號(hào)染色體開(kāi)放閱讀框26抗體
xy-15142R    C2b補(bǔ)體C2b鏈多肽抗體
xy-15147R    C2orf162號(hào)染色體開(kāi)放閱讀框16抗體
xy-15148R    C2orf27 2號(hào)染色體開(kāi)放閱讀框27抗體
xy-12989R    phospho-delta 1 Catenin (Ser268)磷酸化δ連環(huán)蛋白抗體
xy-12990R    phospho-delta 1 Catenin (Thr310)磷酸化δ連環(huán)蛋白抗體
xy-12991R    phospho-delta 1 Catenin (Thr916)磷酸化δ連環(huán)蛋白抗體
xy-12992R    phospho-delta 1 Catenin (Tyr228)磷酸化δ連環(huán)蛋白抗體
xy-12993R    phospho-delta 1 Catenin (Tyr291)磷酸化δ連環(huán)蛋白抗體
xy-12994R    phospho-delta 1 Catenin (Tyr96)磷酸化δ連環(huán)蛋白抗體
xy-15140R    C22orf43 22號(hào)染色體開(kāi)放閱讀框43抗體
xy-15143R    C2CD3C2CD3蛋白抗體
xy-10136R    Caspase 14半胱胺酸蛋白酶蛋白14抗體
xy-15178R    C3orf553號(hào)染色體開(kāi)放閱讀框55抗體
xy-15181R    C3orf653號(hào)染色體開(kāi)放閱讀框65抗體
xy-15165R    C3orf14 3號(hào)染色體開(kāi)放閱讀框14抗體
xy-15167R    C3orf203號(hào)染色體開(kāi)放閱讀框20抗體
xy-15169R    C3orf23 3號(hào)染色體開(kāi)放閱讀框23抗體
xy-15173R    C3ORF31 3號(hào)染色體開(kāi)放閱讀框31抗體
xy-15174R    C3orf323號(hào)染色體開(kāi)放閱讀框32抗體
xy-15176R    C3orf363號(hào)染色體開(kāi)放閱讀框36抗體
xy-15177R    C3orf383號(hào)染色體開(kāi)放閱讀框38抗體
xy-15179R    C3orf583號(hào)染色體開(kāi)放閱讀框58抗體
xy-15180R    C3ORF623號(hào)染色體開(kāi)放閱讀框62抗體
xy-10218R    CD5CD5抗體
xy-15185R    C4BPA 補(bǔ)體C4BPA蛋白抗體
xy-15190R    C4orf29 4號(hào)染色體開(kāi)放閱讀框29抗體
xy-15188R    C4orf214號(hào)染色體開(kāi)放閱讀框21抗體
xy-2568R    CLEC4CC型凝集素結(jié)構(gòu)域家族4成員C抗體
xy-2569R    CD226CD226抗體
xy-2570R    CD26/DPP4CD26抗體