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內(nèi)質(zhì)網(wǎng)分子伴侶SIL1抗體

英文名稱 SIL1
中文名稱 內(nèi)質(zhì)網(wǎng)分子伴侶SIL1抗體
別    名 BAP; BiP associated protein; BiP-associated protein; Endoplasmic reticulum chaperone SIL 1; Endoplasmic reticulum chaperone SIL1; MSS; Nucleotide exchange factor SIL 1; Nucleotide exchange factor SIL1; SIL 1; sil1; SIL1 homolog; SIL1 homolog endoplasmic reticulum chaperone (S. cerevisiae); SIL1 homolog endoplasmic reticulum chaperone; SIL1_HUMAN; UGL 5; ULG5.
    
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, Cat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIL1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

Function:
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.

Subcellular Location:
Endoplasmic reticulum lumen.

Tissue Specificity:
Highly expressed in tissues which produce large amounts of secreted proteins such as kidney, liver and placenta. Also expressed in colon, heart, lung, ovary, pancreas, peripheral leukocyte, prostate, spleen and thymus. Expressed at low levels throughout the brain.

Post-translational modifications:
N-glycosylated.

DISEASE:
Defects in SIL1 are a cause of Marinesco-Sjoegren syndrome (MSS) [MIM:248800]. MSS is an autosomal recessive multisystem disorder which is characterized by cerebellar ataxia due to cerebellar atrophy, with Purkinje and granule cell loss and myopathy featuring marked muscle replacement with fat and connective tissue. Other cardinal features include bilateral cataracts, hypergonadotrophic hypogonadism and mild to severe mental retardation. Skeletal abnormalities, short stature, dysarthria, strabismus and nystagmus are also frequent findings. Mutational inactivation of this protein may result in ER stress-induced cell death signaling or malfunctioning chaperone machineries that mishandle client proteins which are critical for the organs targeted in MSS.

Similarity:
Belongs to the SIL1 family.

Database links:xy-3041R    phospho-c-Abl (Tyr226)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-3042R    phospho-c-Abl (Tyr185)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-5053R    CSNK1G2酪蛋白激酶1γ2抗體
xy-2389R    Coxsackie Adenovirus Receptor柯薩奇病毒蛋白受體B抗體
xy-5996R    CDC4腫瘤抑制因子FBW7抗體
xy-5997R    Cell adhesion molecule 4細(xì)胞粘附分子4抗體
xy-5995R    CAMTA1鈣調(diào)蛋白結(jié)合轉(zhuǎn)錄激活因子1抗體
xy-6518R    CDK5RAP3周期素依賴性激酶5激活結(jié)合蛋白C53抗體
xy-6519R    CENPH著絲粒蛋白H抗體
xy-6042R    Cystatin E半胱氨酸蛋白酶抑制劑6抗體
xy-6024R    CA10碳酸酐酶相關(guān)蛋白/腦蛋白10抗體
xy-2615R    IL-18R alpha/CD218a白細(xì)胞介素-18受體α鏈抗體
xy-3778R    CTCF轉(zhuǎn)錄阻抑蛋白CTCF抗體
xy-3786R    CD1aT淋巴細(xì)胞CD1抗體
xy-4000R    Phospho-CHK2 (ser19)磷酸化細(xì)胞周期檢測(cè)點(diǎn)激酶2抗體
xy-2932R    Clathrin heavy chain網(wǎng)格蛋白重鏈抗體
xy-3845R    CD168透明質(zhì)酸介導(dǎo)細(xì)胞游走受體抗體
xy-9804R    C2orf242號(hào)染色體開放閱讀框24抗體
xy-9809R    C2orf602號(hào)染色體開放閱讀框60抗體
xy-5248R    phospho-CDK7 (Thr170)磷酸化周期素依賴性激酶7抗體
xy-5249R    Phospho-CDK9 (Thr29)磷酸化周期素依賴性激酶9抗體
xy-5250R    phospho-CHEK1 (Ser280)磷酸化細(xì)胞周期檢測(cè)點(diǎn)激酶1抗體
xy-5251R    phospho-CHEK1(Ser317)磷酸化細(xì)胞周期檢測(cè)點(diǎn)激酶1抗體
xy-5253R    phospho-CDKN2A (Ser140)磷酸化抑癌基因p16抗體
xy-5254R    phospho-CDKN2A (Ser152)磷酸化抑癌基因p16抗體
xy-5255R    phospho-CDKN2A (Ser8)磷酸化抑癌基因p16抗體
xy-5256R    phospho-CREB-1(Ser129)磷酸化CREB-1抗體
xy-5252R    phospho-CSF2RB (Tyr766)磷酸化粒細(xì)胞-巨噬細(xì)胞集落刺激因子受體β抗體
xy-5263R    phospho-CDH2 (Tyr820)磷酸化N-鈣粘附分子抗體
xy-5268R    phospho-CDC27 (Thr244)磷酸化后期促進(jìn)復(fù)合蛋白3抗體
xy-5184R    phospho-c-Abl(Tyr283)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-5183R    phospho-c-Abl(Thr735)磷酸化非受體酪氨酸激酶c-Abl抗體
xy-15341R    C9orf759號(hào)染色體開放閱讀框75抗體
xy-0647R    CD4CD4抗體
xy-2347R    CD42b血小板糖蛋白GPIb抗體
xy-4098R    CARM1蛋白精氨酸N甲基4抗體
xy-5285R    phospho-CARM1(Ser228)磷酸化蛋白精氨酸N甲基4抗體
xy-5286R    phospho-CDK6 (Tyr13)磷酸化周期素依賴性激酶6抗體
xy-4072R    phospho-CBL2 (Tyr700)磷酸化原癌基因CBL2抗體
xy-5148R    Cdc7細(xì)胞分裂周期蛋白7抗體
xy-5242R    Phospho-cdc25A (Ser124)磷酸化細(xì)胞分裂周期蛋白25抗體
xy-4094R    Cdc25B細(xì)胞分裂周期蛋白25B抗體