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SGEF蛋白抗體

英文名稱 SGEF
中文名稱 SGEF蛋白抗體
別    名 ARHGEF26; ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26; ARHGQ_HUMAN; CSGEF; DKFZp434D146; HMFN1864; Rho guanine nucleotide exchange factor 26; SH3 domain-containing guanine exchange factor.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Saccharomyces cerevisiae
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 97kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SGEF
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Function:
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

Subcellular Location:
Cell projection > ruffle.

Tissue Specificity:
Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.

Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 26084 Human

Entrez Gene: 622434 Mousexy-15060R    C1orf2261號染色體開放閱讀框226抗體
xy-1508R    Cathepsin L組織蛋白酶L抗體
xy-2937R    CK II beta絲/蘇氨酸蛋白激酶II β抗體(casein kinase IIβ)
xy-2043R    CK18細(xì)胞角蛋白18抗體
xy-6067R    CD109轉(zhuǎn)化生長因子β1結(jié)合蛋白抗體
xy-15141R    C22orf4522號染色體開放閱讀框45抗體
xy-15136R    C22orf3222號染色體開放閱讀框32抗體
xy-2487R    CD5LCD5L抗體
xy-2488R    CD6CD6抗體
xy-2489R    CD9CD9蛋白抗體
xy-2490R    CD23CD23/FcεRII抗體
xy-2491R    CD27CD27抗體
xy-2495R    CD30CD30抗體
xy-2496R    CD43CD43抗體
xy-2497R    CD48CD48抗體
xy-2507R    CD44 CD44抗體
xy-2508R    CD11c整合素αX抗體
xy-2514R    CCR5/CD195細(xì)胞表面趨化因子受體5抗體
xy-2515R    CD2CD2抗體
xy-0274R    C PeptideC-肽抗體
xy-0062R    Calretinin鈣結(jié)合蛋白抗體
xy-0155R    CRPC-反應(yīng)蛋白抗體
xym-0391M    CRP(C11F2)C-反應(yīng)蛋白單克隆抗體
xy-0035M    CREB-1環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白抗體
xy-0246R    CRF促腎上腺皮質(zhì)激素釋放因子抗體
xy-0382R    CRF促腎上腺皮質(zhì)激素釋放因子抗體
xy-15210R    C5orf545號染色體開放閱讀框54抗體
xy-2474R    CD93CD93抗體
xy-2476R    CCL6嗜酸粒細(xì)胞趨化蛋白CCL6抗體
xy-15254R    C6orf816號染色體開放閱讀框81抗體
xy-2475R    CCL4巨噬細(xì)胞炎性蛋白1β抗體
xy-2643R    CD158NK細(xì)胞抑制性受體2DL4抗體
xy-2644R    CD158iNK細(xì)胞抑制性受體2DS4抗體
xy-2645R    CD158eNK細(xì)胞抑制性受體3DL1抗體
xy-15271R    C7orf467號染色體開放閱讀框46抗體