SC35蛋白抗體 返回列表頁(yè)

SC35蛋白抗體

英文名稱 SC35
中文名稱 SC35蛋白抗體
別    名 35 kDa; arginine/serine-rich 2; PR264; Protein PR264; SC 35; SC-35; SC35; Serine/arginine-rich splicing factor 2; SFRS 2; SFRS2; SFRS2A; Splicing component 35 kDa; Splicing component; Splicing factor; Splicing factor arginine/serine rich 2; Splicing factor SC35; Splicing speckle; Splicing speckles; SR splicing factor 2; SRp30b; SRSF2; SRSF2_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Cow, Zebrafish, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SC35
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

Function:
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway.

Subcellular Location:
Nucleus.

Post-translational modifications:
Extensively phosphorylated on serine residues in the RS domain.xy-13841R    Centaurin alpha 2CENTA2蛋白抗體
xy-13843R    CENTB1胞吞再循環(huán)相關(guān)銜接蛋白CENTB1抗體
xy-13844R    phospho-CENTB1 (Ser554)磷酸化胞吞再循環(huán)相關(guān)銜接蛋白CENTB1抗體
xy-13845R    CENTD1CENTD1蛋白抗體
xy-13846R    CENTG3CENTG3蛋白抗體
xy-13847R    Centrin 3中心體蛋白3抗體
xy-13848R    Centrin-1+Centrin-2中心體蛋白1+2抗體
xy-13849R    Centrin 2中心體蛋白2抗體
xy-13850R    CEP120中心體蛋白CEP120抗體
xy-13851R    CEP164中心體蛋白CEP128抗體
xy-13852R    CEP170中心體蛋白CEP170抗體
xy-12301R    CDX4尾型同源盒轉(zhuǎn)錄因子4抗體
xy-11048R    CUTC銅轉(zhuǎn)運(yùn)蛋白CUTC抗體
xy-12931R    CUTL1CUTL1蛋白抗體
xy-12932R    CTNS胱氨酸抗體
xy-12933R    CTRB1胰凝乳蛋白酶B抗體
xy-12934R    CTRP2補(bǔ)體C1q腫瘤壞死因子相關(guān)蛋白2抗體
xy-12935R    CSTF3細(xì)胞分化促進(jìn)因子77抗體
xy-12936R    CSTL1半胱氨酸蛋白酶抑制劑樣蛋白1抗體
xy-12937R    CTBSCTBS蛋白抗體
xy-12938R    CSGALNACT1硫酸軟骨素β1/β-1,4-GalNAc-T抗體
xy-12939R    CSGLCAT硫酸軟骨素聚合酶3抗體
xy-12940R    Placental lactogen I+II胎盤催乳素1/2抗體
xy-12941R    CSK酪氨酸激酶C-SRC抗體
xy-12942R    phospho-CSK (Ser364)磷酸化酪氨酸激酶C-SRC抗體
xy-12943R    CSNK1A1L酪蛋白激酶1/casein kinase Iα抗體
xy-12944R    CSP半胱氨酸延伸蛋白α抗體
xy-12945R    CSPS磺基轉(zhuǎn)移酶CSPS抗體
xy-12946R    CSRP2富含半胱氨酸蛋白2抗體
xy-12948R    CRTAC1軟骨酸性蛋白1抗體
xy-12947R    CSRP2BP富含半胱氨酸蛋白結(jié)合蛋白抗體
xy-12950R    CRTC3CREB調(diào)節(jié)轉(zhuǎn)錄激活因子3抗體
xy-12949R    CRTAP軟骨相關(guān)蛋白CRTAP抗體
xy-15000R    C1orf1001號(hào)染色體開放閱讀框100抗體
xy-15002R    C1orf1041號(hào)染色體開放閱讀框104抗體