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SAFB蛋白抗體

英文名稱 SAFB
中文名稱 SAFB蛋白抗體
別    名 DKFZP779C1727; HAP; HET; hsp27 ere tata binding; KIAA0138; SAF B; SAF B2; SAF-B2; SAFB; SAF-B; SAFB1; SAFB2; SAFB2_HUMAN; Scaffold attachment factor B2
   
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 107kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAFB
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport. hnRNPs also bind heterogeneous nuclear RNA (hnRNA), the transcripts produced by RNA polymerase II. SAF-B (scaffold attachment factor B) is a nuclear matrix-associated protein that binds to matrix- or scaffold-associating regions (MARs or SARs) on DNA and interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors (SR proteins). SAF-B, also designated HAP (hnRNP A1 associated protein) and HET (HSP 27-ERE-TATA-binding protein) is a proven hnRNP protein that has a speckled distribution in the nucleus and, in response to stress agents such as heat shock, is recruited to a few, large nuclear granules, called perichromatin granules. SAF-B also binds to the estrogen receptor (ER) and is expressed in several breast cancer cell lines at varying levels. Subsequently, SAF-B may play a role in breast cancer by mediating cellular proliferation and division.

Function:
Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.xy-3721R    Phospho-CHK2 (Thr68)磷酸化細(xì)胞周期檢測(cè)點(diǎn)激酶2抗體
xy-3999R    CDK11周期素依賴性激酶11抗體
xy-2361R    CDK10周期素依賴性激酶10
xy-15305R    C8orf868號(hào)染色體開(kāi)放閱讀框86抗體
xy-5243R    phospho-Cdc25B (Ser323)磷酸化細(xì)胞分裂周期蛋白25B抗體
xy-5244R    phospho-Cdc25B (Ser186)磷酸化細(xì)胞分裂周期蛋白25B抗體
xy-5240R    phospho-Caspase 6 (Ser257)磷酸化半胱胺酸蛋白酶蛋白6抗體
xy-15320R    C9orf1729號(hào)染色體開(kāi)放閱讀框172抗體
xy-5227R    phospho-CDKN1B (Ser10)磷酸化P27抗體/周期素依賴激酶抑制劑
xy-9383R    CNOT2細(xì)胞表面趨化因子受體4相關(guān)蛋白2抗體
xy-5047R    CPT2肉毒堿棕櫚酰基轉(zhuǎn)移酶2抗體
xy-5048R    CROT肉堿氧位甲基轉(zhuǎn)移酶抗體
xy-5044R    COL4A3BPIV型膠原α3結(jié)合蛋白抗體
xy-5045R    CPT1B肉毒堿棕櫚?；D(zhuǎn)移酶1B抗體
xy-5049R    CYP27A1膽固醇27α羥化酶抗體
xy-5050R    CYP39A1膽固醇24α7羥化酶抗體
xy-5054R    CYP4A1細(xì)胞色素P450 4A1抗體
xy-5055R    CYP4A22細(xì)胞色素P4504A22抗體（脂肪酸Ω羥化酶）
xy-5982R    CDKN2D細(xì)胞周期蛋白依賴性激酶抑制劑2D抗體
xy-5046R    CYP46膽固醇24S－羥化酶
xy-4528R    CSFV Polyprotein豬瘟病毒抗體
xy-2376R    Cytochrome c oxidase subunit 2細(xì)胞色素c氧化酶亞型2抗體
xy-3822R    Cyclin G2周期素G2抗體
xy-2373R    Ceruloplasmin銅藍(lán)蛋白抗體
xy-4608R    CUEDC2CUE結(jié)構(gòu)域蛋白2抗體
xy-3890R    NDUFS1(75kD)線粒體復(fù)合物NDUFS1蛋白抗體
xy-4019R    Thromboxane synthase血栓素合成酶抗體
xy-3878R    CQ028多癌基因下調(diào)蛋白抗體
xy-3931R    COX 5B細(xì)胞色素C氧化酶蛋白5B抗體
xy-3934R    COX3細(xì)胞色素C氧化酶亞基3抗體
xy-3935R    COX6B細(xì)胞色素C氧化酶亞基6B抗體
xy-4017R    phospho-C-Myc(Thr358)磷酸化致癌基因C-Myc抗體
xy-4018R    phospho-C-Myc (Thr373)磷酸化致癌基因C-Myc抗體