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清道夫受體B1+B2抗體

英文名稱 Scavenger Receptor BI + BII
中文名稱 清道夫受體B1+B2抗體
別    名 85 kDa lysosomal membrane sialoglycoprotein; CD36 and LIMPII Analogous 1; CD36L1; CD36L2; CLA1; HLGP85; LGP85; LIMP II; Lysosome membrane protein II; MGC138242; SCARB1; SCARB2;
說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Scavenger Receptor BI + BII
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Function:
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximay 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not compley clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Subcellular Location:
Lysosome; lysosomal membrane; multi-pass membrane protein. xy-7345R    DLL1Notch信號通路Delta樣配體1抗體
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xy-4290R    CDC37Hsp90輔助伴侶分子CDC37抗體
xy-6718R    Dystrophin肌營養(yǎng)不良蛋白抗體
xy-3577R    Dematin金屬離子轉(zhuǎn)運(yùn)體1抗體
xy-2162R    DKK1抑癌蛋白DKK1抗體
xy-11549R    Dispatched膜轉(zhuǎn)運(yùn)蛋白DISPA抗體
xy-13003R    DIRAS2DIRAS2蛋白抗體
xy-0993R    DDX58DDX58抗體
xy-3597R    DDX4DDX4抗體
xy-1672R    Duck plague virus鴨瘟病毒DPV抗體
xy-3514R    D-DIMER交聯(lián)纖維蛋白二聚體抗體
xy-5835R    Drebrin腦發(fā)育調(diào)節(jié)蛋白抗體
xy-7648R    DFFBDNA斷裂因子抗體（蛋白酶激活脫氧核糖核酸酶）
xy-7653R    DNase gamma脫氧核糖核酸酶γ抗體
xy-7659R    DATF1死亡相關(guān)轉(zhuǎn)錄因子1抗體
xy-7651R    DNase I脫氧核糖核酸酶1抗體
xy-7652R    DNase II脫氧核糖核酸酶2抗體
xy-6800R    DAD1細(xì)胞死亡防衛(wèi)蛋白1抗體
xy-7592R    DARCDuffy血型趨化因子受體抗體
xy-0874R    DEKDEK癌基因結(jié)合蛋白
xy-12138R    DLGAP1PSD95結(jié)合蛋白1抗體
xy-12139R    DLGAP2PSD95結(jié)合蛋白2抗體
xy-12140R    DLGAP4PSD95結(jié)合蛋白4抗體
xy-7065R    DPF2雙PHD-D4鋅指蛋白2抗體
xy-7066R    DUSP22雙特異性磷酸酶22抗體
xy-1276R    DNAJC10Erdj5/DNAJC10蛋白抗體
xy-7678R    DR6腫瘤細(xì)胞調(diào)亡素/腫瘤壞死因子受體死亡受體6抗體
xy-9427R    TMIGD1跨膜TMIGD1蛋白抗體