同類型染色單體凝聚蛋白4抗體 返回列表頁

同類型染色單體凝聚蛋白4抗體

英文名稱 SCC4
中文名稱 同類型染色單體凝聚蛋白4抗體
別    名 K0892; KIAA0892; Mau 2; Mau 2L; mau-2; Mau2; SCC4_HUMAN; MAU2L; Scc 4; SCC4; sister chromatid cohesion 4.

說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  免疫學  染色質和核信號  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCC4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3.

Function:
Scc4 (Mau2) is the metazoan homologue of Scc4 in S. cerevisiae. In yeast, Scc4 binds to Scc2 to form an essential complex that loads cohesion onto chromosomes. Similarly, the Scc4 / Mau2 protein in metazoans plays a significant role in sister chromatid separation and in loading of cohesin onto chromatin. The Scc2-Scc4 complex is tethered to pre-replication complexes through the Cdc7-Drf1 protein kinase DDK. 

Subunit:
Interacts (via N-terminus) with NIPBL to form the cohesion loading complex.

Subcellular Location:
Nucleus, nucleoplasm. Note=Binds to chromatin from the end of mitosis until prophase.

Similarity:
Belongs to the SCC4/mau-2 family.
Contains 4 TPR repeats. xy-11024R    DNAI1 + 2軸絲中鏈動力蛋白抗體
xy-11023R    DNAH7軸絲動力蛋白7抗體
xy-11778R    DORFIN環(huán)指蛋白19抗體
xy-11679R    delta 2 Cateninδ-連環(huán)蛋白抗體
xy-4307R    beta 2 Defensin防御素β2抗體
xy-11044R    phospho-DAB2 (Ser24)磷酸化信號轉導功能磷蛋白DAB2抗體
xy-11431R    DUOX1雙氧化酶1/甲狀腺氧化酶1抗體
xy-11432R    DUOX2雙氧化酶2/甲狀腺氧化酶2抗體
xy-11433R    DUOXA1雙氧化酶成熟因子抗體
xy-11825R    DOCK7胞質分裂專一蛋白7抗體
xy-6376R    DDIT4LDNA損傷誘導轉錄樣蛋白4抗體
xy-7625R    DAP3死亡相關蛋白3抗體
xy-7129R    Defensin alpha 6防御素α6抗體
xy-5748R    DBF4BS期激酶活化蛋白DBF4B抗體
xy-5749R    DCK脫氧胞苷激酶抗體
xy-2286R    DHRS3短鏈脫氫還原酶3抗體
xy-13022R    DNA Polymerase theta/POLHDNA聚合酶θ/DNA pol θ抗體
xy-9668R    DENND2DDENN域內含蛋白2D抗體
xy-5152R    Alpha Dystroglycan肌萎縮相關蛋白DAG1抗體
xy-4075R    phospho-DAG1 (Tyr892)磷酸化肌萎縮相關蛋白DAG1抗體
xy-5303R    phospho-DAAM1 (Thr361)磷酸化形態(tài)發(fā)生紊亂關聯(lián)激活因子1抗體
xy-5290R    phospho-DOK1 (Tyr398)磷酸化D酪氨酸激酶衰減蛋白1抗體
xy-5288R    phospho-DAXX (Ser213)磷酸化Fas相關死亡結構域蛋白抗體
xy-5289R    phospho-DOK1(Tyr362)磷酸化D酪氨酸激酶衰減蛋白1抗體
xy-5291R    phospho-DAXX (Ser495)磷酸化Fas相關死亡結構域蛋白抗體
xy-5292R    phospho-DAXX (Ser517)磷酸化Fas相關死亡結構域蛋白抗體
xy-5293R    phospho-DAXX (Ser671)磷酸化Fas相關死亡結構域蛋白抗體
xy-5294R    phospho-Dnmt1(Ser154)磷酸化DNA甲基轉移酶1抗體
xy-5295R    phospho-Dnmt1(Ser732)磷酸化DNA甲基轉移酶1抗體
xy-5296R    phospho-Dnmt1(Tyr399)磷酸化DNA甲基轉移酶1抗體
xy-5057R    DHCR77脫氫膽固醇還原酶抗體
xy-8173R    Dbx2大腦發(fā)育同源蛋白2抗體
xy-4057R    DEGS1退行性精母細胞同源物1抗體
xy-7720R    DSCC1DSCC1蛋白抗體