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冠狀病毒p65蛋白抗體

英文名稱 SARS p65
中文名稱 冠狀病毒p65蛋白抗體
別    名 ORF1AB; p65 polyprotein; pp1ab; Replicase polyprotein 1ab.
 
說 明 書 0.2ml  
研究領域 細胞生物  細菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Reacts with SARS Coronavirus
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 91kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SARS p65
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive stranded RNA approximay 27 to 31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin converting enzyme 2 (ACE2) on target cells. p65 is the replicase polyprotein of coronaviruses, and is a multifunctional protein. It contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products. It is responsible for the cleavages located at the N terminus of replicase polyprotein and its activity is dependent on zinc. p65 exists as monomer and homodimer. The Cys rich growth factor like peptide forms a homodimer. The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane. p65 is translated as a 1a-1b polyprotein by a ribosomal frameshifting mechanism. The 1A polyprotein is produced by itself but not the 1B polyprotein.xy-8153R    FAM134CFAM134C蛋白抗體
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