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SAV1蛋白抗體

英文名稱 SAV1
中文名稱 SAV1蛋白抗體
別    名 1700040G09Rik; 45 kDa WW domain protein; hWW 45; hWW45; Protein salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1; SAV 1; SAV; SAV1; SAV1_HUMAN; WW 45; WW domain containing; WW45; WW45 protein; WWP 4; WWP4.

說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  信號轉(zhuǎn)導  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
細胞定位 細胞核 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SAV1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

Function:
Regulator of MST1/MST2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for MST1/MST2 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.

xy-8223R    FAM155AFAM155A蛋白抗體
xy-8227R    FAM164BFAM164B蛋白抗體
xy-8234R    FRMD3FRMD3蛋白抗體
xy-8236R    FRMD4BFRMD4B蛋白抗體
xy-8239R    FRMD7FRMD7蛋白抗體
xy-8235R    FRMD4AFRMD4A蛋白抗體
xy-8228R    FAHD2A延胡索酰乙酰乙酸水解酶抗體
xy-8229R    FAM101AFAM101A蛋白抗體
xy-8230R    FAM102BFAM102B蛋白抗體
xy-8231R    FAM104BFAM104B蛋白抗體
xy-6381R    FAM107A腎細胞癌下調(diào)蛋白1抗體
xy-2974R    Factor VIII凝血因子8/第八凝血因子/第八因子相關(guān)抗原抗體
xy-9595R    FOLR2胎盤葉酸受體蛋白2抗體
xy-5757R    FAM13B1FAM13B1蛋白抗體
xy-6280R    FUT8巖藻糖轉(zhuǎn)移酶8抗體
xy-13193R    FNIP1卵泡刺激素結(jié)合蛋白1抗體
xy-5157R    FHL2相互作用蛋白FHL2抗體
xy-5060R    FADS1脂肪酸去飽和酶1抗體
xy-5059R    FABP6回腸脂肪酸結(jié)合蛋白抗體
xy-4059R    FABP4脂肪細胞型脂肪酸結(jié)合蛋白
xy-5061R    FAR2脂肪酰輔酶A還原酶2抗體
xy-6975R    FXR2脆性X相關(guān)蛋白樣2抗體
xy-5119R    FAAH2脂肪酸酰胺水解酶2抗體
xy-5125R    Frizzled 7卷曲蛋白FZD7抗體
xy-4523R    FMDV Polyprotein (VPg2 protein)口蹄疫病毒A型抗體
xy-3163R    Phospho-FAK (Tyr925)磷酸化粘著斑激酶抗體
xy-1240R    human Fibrinogen人纖維蛋白原抗體
xy-13174R    FIZ1鋅指蛋白798抗體
xy-13175R    FKBP10肽基脯氨酰順反異構(gòu)酶FKBP10抗體
xy-13176R    FKBP11肽基脯氨酰順反異構(gòu)酶FKBP11抗體

xy-13208R    phospho-FOXO4 (Thr451)磷酸化叉頭蛋白4抗體
xy-13209R    FOXRED1單跨膜蛋白FOXRED1抗體
xy-13210R    FOXRED2FOXRED2蛋白抗體
xy-13211R    FPGT巖藻糖1磷酸鳥苷酰轉(zhuǎn)移酶抗體
xy-13213R    FREM1細胞外基質(zhì)蛋白FREM1抗體
xy-12434R    FRAT1原癌基因FRAT1抗體
xy-12193R    FOXD1叉頭蛋白D1抗體
xy-10336R    Factor XI heavy chain凝血因子11重鏈抗體
xy-10337R    Factor XII light chain凝血因子12輕鏈抗體
xy-0879R    FLAG Tag (CT)FLAG Tag標簽抗體（C端）
xy-10339R    Factor I heavy chain補體因子I重鏈抗體
xy-10417R    Factor VIIIa light chain凝血因子8/第八凝血因子/第八因子相關(guān)抗原輕鏈抗體
xy-3144R    phospho-FOXO4 (Ser197)磷酸化叉頭蛋白4抗體
xy-3145R    phospho-FOXO4 (Ser262)磷酸化叉頭蛋白4抗體
xy-2572R    FPR1甲酸基肽受體1抗體
xy-5539R    phospho-FAK(Ser722)磷酸化粘著斑激酶抗體