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跨膜接頭蛋白SIT抗體

英文名稱 SIT
中文名稱 跨膜接頭蛋白SIT抗體
別    名 gp30/40; SHP intracting transmembrane adapter protein; SHP2-interacting transmembrane adapter protein; Signaling threshold-regulating transmembrane adapter 1; SIT; Sit1; SIT1_HUMAN; Suppression inducing transmembrane adapter 1; Suppression-inducing transmembrane adapter 1.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  淋巴細(xì)胞  t-淋巴細(xì)胞  b-淋巴細(xì)胞  跨膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIT
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Function:
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.

Subcellular Location:
Cell membrane.xy-9738R    FASP1MaFF相關(guān)蛋白抗體
xy-4846R    Factor VII凝血因子7抗體
xy-7113R    FEM 1BFEM1B抗體
xy-1255R    FGF3纖維母細(xì)胞生長因子3抗體
xy-1256R    FGF4纖維母細(xì)胞生長因子4抗體
xy-1154R    FRA1FRA-1蛋白抗體
xy-12264R    FTSJ1精神發(fā)育遲滯相關(guān)蛋白抗體
xy-12165R    FAM62C延伸突觸蛋白3抗體
xy-12166R    Fibrillin 2原纖維蛋白2抗體
xy-7662R    FLI1尤文肉瘤FLI1蛋白抗體
xy-7636R    FUT1巖藻糖轉(zhuǎn)移酶1抗體
xy-6766R    FLIP delta + gamma凋亡調(diào)節(jié)蛋白δ+γ抗體
xy-7068R    FOXO1 + FOXO3 + FOXO4叉頭蛋白O1/O3/O4抗體
xy-9730R    FAM82B微管相關(guān)蛋白FAM82B抗體
xy-7548R    Fibrinogen alpha chain纖維蛋白原A鏈抗體
xy-7061R    FAIM1FAS凋亡抑制分子1抗體
xy-6831R    FAIM2FAS凋亡抑制分子2
xy-11254R    Flotillin 2表皮細(xì)胞表面抗原1抗體
xy-9500R    Factor IX凝血因子9抗體
xy-9501R    Factor X凝血因子10抗體
xy-9502R    Factor XI light chain凝血因子11輕鏈抗體
xy-9503R    Factor XII heavy chain凝血因子12重鏈抗體
xy-9433R    FIGNL1FIGNL1蛋白抗體
xy-11006R    FAM70AFAM70A蛋白抗體
xy-9546R    FIBCD1含纖維蛋白原C結(jié)構(gòu)域蛋白1抗體
xy-6415R    FbxO6F-box蛋白相關(guān)蛋白6抗體
xy-7902R    phospho-FRS2(Tyr436)磷酸化成纖維細(xì)胞生長因子受體底物2抗體
xy-11840R    FEZ2椎骨蛋白2抗體
xy-7760R    Factor VII light chain凝血因子VII
xy-7762R    Factor X heavy chain凝血因子10抗體
xy-11703R    AFF2脆性X綜合征相關(guān)蛋白AFF2抗體