可溶性P選擇素抗體 返回列表頁

可溶性P選擇素抗體

英文名稱 sp-selectin
中文名稱 可溶性P選擇素抗體
別    名 CD62 antigen-like family member P; CD62P; GMP 140; GMP-140; GMRP; Granule membrane protein 140; Granulocyte membrane protein; GRMP; LECAM 3; LECAM3; Leukocyte endothelial cell adhesion molecule 3; Leukocyte-endothelial cell adhesion molecule 3; LYAM3_HUMAN; P Selectin; P-selectin; PADGEM; Plaet activation dependent granule-external membrane protein; PSEL.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞粘附分子  細(xì)胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 86kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human sp-selectin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
sp-selectin is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated plaets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human plaet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.

Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or plaets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Subunit : Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
Stored in the alpha-granules of plaets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.xy-15392R    GPR91G蛋白偶聯(lián)受體GPR91蛋白抗體
xy-4241R    GLUT8葡萄糖轉(zhuǎn)運(yùn)蛋白8抗體
xy-6622R    Glycophorin C糖蛋白C抗體
xy-6617R    GABA Transporter 1γ氨基丁酸運(yùn)載蛋白1抗體
xy-6616R    GATA2GATA結(jié)合蛋白2抗體
xy-4279R    Growth Arrest Specific Protein 7生長休止特定蛋白7抗體
xy-8454R    phospho-GluR1 (Ser836)磷酸化谷氨酸受體1抗體
xy-12025R    GPR116G蛋白偶聯(lián)受體116抗體
xy-4109R    G protein alpha 12鳥苷酸調(diào)節(jié)蛋白12抗體
xy-5355R    phospho-GFAP (Ser8)磷酸化膠質(zhì)纖維酸性蛋白抗體
xy-5356R    phospho-GABBR2 (Ser783)磷酸化G氨基丁酸B型受體2抗體
xy-5357R    phospho-GABBR2 (Ser892) 磷酸化G氨基丁酸B型受體2抗體
xy-5720R    GDF10生長分化因子10抗體（TGF-β超家族10）
xy-15369R    GPCR LOC51210G蛋白偶聯(lián)受體LOC51210蛋白抗體
xy-5715R    GIG34細(xì)胞生長抑制蛋白34
xy-6579R    Growth Hormone生長激素抗體
xy-13460R    GMPPAGDP甘露糖焦磷酸化酶抗體
xy-6564R    GPR171G蛋白偶聯(lián)受體171抗體
xy-11847R    GPM6B神經(jīng)細(xì)胞膜糖蛋白M6b
xy-6247R    GUK1鳥苷酸激酶GMK抗體
xy-4691R    Galactocerebroside半乳糖腦苷脂酶抗體
xy-7540R    GRK5G蛋白偶聯(lián)受體激酶5抗體
xy-7502R    GTP binding protein REM1GTP結(jié)合蛋白REM1抗體
xy-4692R    phospho-GSK3 Alpha(Ser21)磷酸化糖原合酶激酶-3α抗體
xy-11461R    GDF7生長分化因子7抗體
xy-7057R    Glucokinase regulatory protein葡萄糖激酶調(diào)節(jié)蛋白抗體
xy-8402R    GCLCγ谷氨酰半胱氨酸合成酶抗體（γ-GCSc）
xy-8403R    GCOM1GCOM1蛋白抗體
xy-8405R    GFOD2葡萄糖果糖還原酶2抗體
xy-8406R    GFRAL膠質(zhì)細(xì)胞系源性神經(jīng)營養(yǎng)因子受體α1樣蛋白抗體
xy-8407R    GHDCGHDC蛋白抗體
xy-8408R    GK5甘油激酶5抗體
xy-8409R    GLB1L3β半乳糖苷酶1樣蛋白3抗體
xy-8410R    GLCCI1糖皮質(zhì)激素誘導(dǎo)轉(zhuǎn)錄蛋白1抗體
xy-8411R    GLIPR2腦膠質(zhì)瘤發(fā)病相關(guān)蛋白2抗體
xy-11725R    GDAP1神經(jīng)節(jié)苷脂誘導(dǎo)分化相關(guān)蛋白1抗體