IL-1相關(guān)Ig受體抗體 返回列表頁

IL-1相關(guān)Ig受體抗體

英文名稱 SIGIRR
中文名稱 IL-1相關(guān)Ig受體抗體
別    名 Ig IL1 related receptor; MGC110992; SIGIR_HUMAN; SIGIRR; Single Ig IL 1 related receptor; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; Single Ig IL1R Related Molecule; Single immunoglobulin and toll interleukin 1 receptor (TIR) domain; Single immunoglobulin and toll interleukin 1 receptor domain; Single immunoglobulin domain containing IL1R related protein; Single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; TIR 8; TIR8; Toll/interleukin 1 receptor 8; Toll/interleukin-1 receptor 8.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIGIRR
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Single Ig IL-1-related receptor SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut.

Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.xy-12015R    GPR18G蛋白偶聯(lián)受體18抗體
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xy-11850R    Glutathione Synthetase谷胱甘肽合成酶抗體
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xy-12078R    GABRG1G氨基丁酸受體γ1/GABAA Rγ1抗體
xy-12079R    phospho-GABRG2(Ser366)磷酸化γ氨基丁酸γ2受體抗體
xy-12080R    GABRG3G氨基丁酸受體γ3/GABAA Rγ3抗體
xy-12081R    GABAREG氨基丁酸受體ε/GABAA Rε抗體
xy-12082R    GABARAPγ-氨基丁酸受體相關(guān)蛋白抗體
xy-12083R    GABRQG氨基丁酸A型受體θ/GABAA Rθ抗體
xy-12084R    GABRR1G氨基丁酸A型受體rho1 /GABAA Rρ1抗體
xy-12085R    GABRR2G氨基丁酸A型受體rho2 /GABAA Rρ2抗體
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