富含亮氨酸重復(fù)結(jié)構(gòu)域蛋白6抗體 返回列表頁(yè)

富含亮氨酸重復(fù)結(jié)構(gòu)域蛋白6抗體

英文名稱 NALP6
中文名稱 富含亮氨酸重復(fù)結(jié)構(gòu)域蛋白6抗體
別    名 CLR11.4; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD containing protein 6; NACHT, LRR and PYD domains-containing protein 6; NALP6_HUMAN; NLR family, pyrin domain containing 6; Nlrp6; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PAN3; PYPAF5; PYRIN containing APAF1 like protein 5; PYRIN-containing APAF1-like protein 5.
 
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  Alzheimer's  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human NALP6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Function:
May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Isoform 1 binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Isoform 2 binds both arginine-vasopressin and angiotensin II and acts as an angiotensin II/vasopressin receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevola species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation.xy-13457R    GMFG膠漿成熟因子γ/GMF-γ抗體
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xy-15391R    GPR89AG蛋白偶聯(lián)受體GPR89A蛋白抗體
xy-15393R    GPRASP2G蛋白偶聯(lián)受體GPRSP2蛋白抗體
xy-15394R    GPRC5CG蛋白偶聯(lián)受體GPRC5C蛋白抗體
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xy-13466R    GNB5G蛋白β5/Gβ 5 抗體
xy-13468R    GNG13G蛋白γ13/Gγ13 抗體
xy-13469R    GNG5G蛋白γ5/Gγ5 抗體
xy-13470R    GNGT1G蛋白γ 1/Gγ 1 抗體
xy-13471R    GNL2鳥(niǎo)嘌呤核苷酸結(jié)合蛋白2抗體
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xy-13476R    GNPTAB溶酶體累積病相關(guān)蛋白/口吃相關(guān)蛋白抗體
xy-13477R    GNPTG溶酶體累積病相關(guān)蛋白/口吃相關(guān)蛋白抗體
xy-13478R    GNRH2促性腺激素釋放激素2抗體
xy-13479R    GNS氨基葡萄糖6-硫酸酯酶抗體
xy-13480R    GOLGA3高爾基體膜相關(guān)蛋白抗體
xy-13481R    GOLGA5高爾基體膜相關(guān)蛋白5抗體
xy-13484R    GOLGA7高爾基體膜相關(guān)蛋白7抗體
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