細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白6抗體 返回列表頁

細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白6抗體

英文名稱 SOCS6
中文名稱 細(xì)胞因子信號(hào)傳導(dǎo)抑制蛋白6抗體
別    名 CIS-4; CIS4; Cish4; Cytokine inducible SH2 protein 4; Cytokine-inducible SH2 protein 4; HSPC060; SOCS-4; SOCS-6; SOCS4; Socs6; SOCS6_HUMAN; SSI4; STAI4; STAT induced STAT inhibitor 4; STAT4; STATI4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SOCS6
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008].

Function:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Subunit:
Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated).xy-12266R    GGNBP1配子生成素結(jié)合蛋白1抗體
xy-12267R    GGNBP2鋅指蛋白403/喉癌相關(guān)蛋白1抗體
xy-13545R    Guanylyl Cyclase alpha 2鳥苷酸環(huán)化酶α2/GCS-α-2抗體
xy-8618R    GPR7G蛋白偶聯(lián)受體7抗體
xy-13496R    GPAA1糖基磷脂酰肌醇錨連接蛋白1抗體
xy-13497R    GPAT23-磷酸甘油酰基轉(zhuǎn)移酶2抗體
xy-13501R    GPATCH4G蛋白修補(bǔ)結(jié)構(gòu)域蛋白4抗體
xy-13503R    GPBP1富含GC啟動(dòng)子結(jié)合蛋白1/血管壁相連蛋白抗體
xy-13504R    GPBP1L1血管壁相連蛋白樣蛋白1抗體
xy-13505R    GPR 151G蛋白偶聯(lián)受體151抗體
xy-13506R    GPR77G蛋白偶聯(lián)受體77抗體
xy-13324R    GDI1精神發(fā)育遲滯相關(guān)蛋白R(shí)ab GDI α抗體
xy-13325R    GDPD1甘油磷酸二酯酶磷酸結(jié)構(gòu)域4抗體
xy-13342R    GFPT2D-果糖6磷酸轉(zhuǎn)移酶2抗體
xy-13261R    GABPAGA結(jié)合蛋白轉(zhuǎn)錄因子α/GABP-α抗體
xy-13262R    GABPB2GA結(jié)合蛋白轉(zhuǎn)錄因子β/GABP-β1/GABP-β2抗體
xy-13263R    GAD65 + GAD67谷氨酸脫羧酶65+谷氨酸脫羧酶67抗體
xy-13264R    GADL1谷氨酸脫羧酶樣蛋白1抗體
xy-13253R    G6PC3葡萄糖-6-磷酸酶3/G6Pase-β抗體
xy-13254R    GAAα葡萄糖苷酶/溶酶體α-葡糖苷酶抗體
xy-13255R    GAB3生長因子受體結(jié)合蛋白2相關(guān)蛋白3抗體
xy-13256R    GAB4生長因子受體結(jié)合蛋白2相關(guān)蛋白4抗體
xy-13257R    GABA A receptor piG氨基丁酸受體pi/GABAA Rπ抗體
xy-13258R    phospho-GABBR2 (Ser884)磷酸化G氨基丁酸B型受體2抗體
xy-13241R    GNA11G蛋白偶聯(lián)受體結(jié)合蛋白α11/Gα 11 抗體
xy-13252R    G3BP2G3BP2蛋白抗體
xy-13259R    GABA Transporter 2γ氨基丁酸運(yùn)載蛋白2抗體
xy-13317R    GCNT3β1-6 N-乙酰氨基葡萄糖轉(zhuǎn)移酶3抗體
xy-13319R    GCNT7β1-6 N-乙酰氨基葡萄糖轉(zhuǎn)移酶7抗體
xy-13320R    GCP4γ-微管蛋白GCP4抗體
xy-13321R    GCP6γ-微管蛋白GCP6抗體
xy-13322R    GCS1β-葡萄糖苷酶1抗體