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淋巴細胞胞漿蛋白2抗體

英文名稱 SLP76
中文名稱 淋巴細胞胞漿蛋白2抗體
別    名 76 kDa tyrosine phosphoprotein; CG8697; LCP 2; LCP 2; LCP2; LCP2_HUMAN; Lymphocyte Cytosolic Protein 2; Lymphocyte Cytosolic Protein 2; SH2 Domain Containing Leukocyte Protein 76 KD; SH2 domain containing leukocyte protein of 76kD; SH2 domain containing leukocyte protein of 76kDa; SH2 domain-containing leukocyte protein of 76 kDa; SLP 76; SLP 76; SLP 76 tyrosine phosphoprotein; SLP-76 tyrosine phosphoprotein; SLP76; SLP76 tyrosine phosphoprotein.

說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  信號轉導  激酶和磷酸酶  細胞膜受體  細胞分化  淋巴細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLP76
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation. However, the biochemical basis of Vav’s function is unclear. Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR). Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production. When co-expressed, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response. Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, serine/threonine or lipid kinase families, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1. The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation.

Function:
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xy-4063R    phospho-HMGCR(Ser872)磷酸化三羥基*基輔酶A還原酶抗體
xy-5071R    HSD3a羥基類固醇脫氫酶3α抗體
xy-8174R    HLX1同源異型盒基因HLX1蛋白抗體
xy-5069R    HMGCS1三羥基*基輔酶A合成酶1
xy-3757R    HSF1熱休克因子1抗體
xy-3741R    phospho-HSF1(Ser326)磷酸化熱休克因子1抗體
xy-5117R    Hsc70熱休克蛋白71抗體
xy-5124R    hHBrk1微絲相關蛋白hHBrk1抗體
xy-4046R    HPCL2植烷酰輔酶A羥化酶2抗體
xy-4544R    H9N1 NeuraminidaseA型流感病毒H9N1神經(jīng)氨酸酶型抗體
xy-4543R    H9N1 HemagglutininA型流感病毒H9N1血凝素型抗體
xy-2969R    HPV33 E7人類乳頭狀瘤病毒33抗體
xy-4552R    H1N1 Matrix Protein 1A型禽流感病毒H1N1蛋白抗體
xy-6950R    Hepatitis A virus polyprotein VP1甲型肝炎病毒聚蛋白VP1抗體
xy-5109R    HCLS1造血干細胞特異性蛋白抗體
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xy-12196R    HOXC4同源盒蛋白C4抗體
xy-12197R    HOXD13同源盒蛋白D13抗體
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