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轉(zhuǎn)錄因子SOX17抗體

英文名稱 SOX17
中文名稱 轉(zhuǎn)錄因子SOX17抗體
別    名 SOX-17; SOX17_HUMAN; SRY (sex determining region Y) box 17; SRY box 17; SRY related HMG box transcription factor SOX17; Transcription factor SOX-17; Transcription factor SOX17.
 
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 發(fā)育生物學(xué)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Pig, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from Human SOX17
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

Function:
Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells.

Subunit:
Interacts with CTNNB1, LEF1 and TCF4 (By similarity). 

Subcellular Location:
Nucleus.xy-4281R    HAUSP皰疹病毒相關(guān)泛素特異性蛋白酶7抗體
xy-5713R    HOXA5同源異型盒基因HOXA5蛋白抗體
xy-3825R    HP1 alpha異染色質(zhì)蛋白1-α(HP1α)抗體
xy-3826R    Histone H4組蛋白H4抗體
xy-3746R    Acetyl-Histone H4(K12)乙酰化組蛋白H4抗體
xy-3768R    Histone H3 (tri methyl K36) *基化組蛋白H3抗體
xy-3769R    Histone H3 (Di Methyl K36)二甲基化組蛋白H3抗體
xy-3770R    Histone H3 (Di Methyl K4)二甲基化組蛋白H3K4抗體
xy-3772R    Histone H3 (Di Methyl K9)二甲基化組蛋白H3K9抗體
xy-3773R    Histone H3 (Tri Methyl K27)*基化組蛋白H3抗體
xy-3774R    Acetyl-Histone H3(K23)乙酰化組蛋白H3抗體
xy-3775R    Acetyl-Histone H3(K18)乙酰化組蛋白H3抗體
xy-8451R    phospho-HNF4 (Ser304)磷酸化肝細(xì)胞核因子4α抗體
xy-4113R    HMG14高遷移率核小體結(jié)合蛋白1
xy-5385R    Phospho-Histone H3 (Ser28)磷酸化組蛋白H3抗體
xy-6968R    HLA DM組織相容性復(fù)合體α抗體
xy-6195R    HGFA Inhibitor 2肝細(xì)胞生長(zhǎng)因子激活抑制蛋白2抗體
xy-4632R    HOMER2HOMER2抗體
xy-6567R    HDBP2乳頭瘤病毒調(diào)控因子1抗體（鋅指蛋白395）
xym-0991M    HPV18 E6 protein人類乳頭狀瘤病毒18 E6單克隆抗體
xy-4205R    hnRNP F異質(zhì)核糖核蛋白F抗體
xy-4296R    hnRNP K異質(zhì)核糖核蛋白K抗體
xy-4300R    hnRNP L異質(zhì)核糖核蛋白L抗體
xym-2156M    HER2 receptor(1A4) HER2受體單克隆抗體
xy-6228R    HRG beta 1乳腺癌細(xì)胞分化因子P45抗體 Heregulinβ
xy-6615R    Hepatic lipase肝脂酶抗體
xy-5387R    phospho-HDAC1 (Ser423)磷酸化組蛋白去乙?；?抗體
xy-6107R    HLTF解旋酶樣轉(zhuǎn)錄因子抗體
xy-5070R    HMGCS2三羥基*基輔酶A合成酶2抗體
xy-2355R    HLA Class 1 ABC人類白細(xì)胞抗原A抗體
xy-3856R    HSD17B2羥類固醇脫氫酶17β2抗體
xy-3855R    HSD17B1羥類固醇脫氫酶17β-HSD抗體
xym-2741M    Hepatocyte(2H5)人肝細(xì)胞單克隆抗體/肝細(xì)胞特異性抗原抗體
xym-0287M    His tag(2D5)小鼠抗聚組氨酸單克隆抗體