細胞膜調控蛋白Paralemmin 1抗體 返回列表頁

細胞膜調控蛋白Paralemmin 1抗體

英文名稱 Paralemmin 1
中文名稱 細胞膜調控蛋白Paralemmin 1抗體
別    名 KIAA0270; PALM; PALM_HUMAN; Paralemmin; Paralemmin1;Paralemmin-1.
    
說 明 書 0.2ml  
研究領域 細胞生物  神經生物學  信號轉導  G蛋白偶聯(lián)受體  G蛋白信號  細胞膜蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
細胞定位 細胞漿 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Paralemmin 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
Paralemmin, also called Paralemmin-1 or PALM, is a widely expressed peripheral membrane protein that is involved in cell structure and shape. A hydrophobic protein, Paralemmin is anchored to the cytoplasmic side of the cell membrane via di-palmitoylation and prenylation of its C-terminal cysteine cluster. Functioning at the synapse to regulate neuronal plasticity and plasma membrane dynamics, Paralemmin can bind to the dopamine receptor D3, thereby reducing D3 expression and subsequent adenylate cyclase activity. Overexpression of Paralemmin induces fibroblasts to extend long filopodia and to assume extreme cell shapes, suggesting involvement in the formation and stabilization of the plasma membrane. Two isoforms of Paralemmin exists due to alternative splicing events.

Function:
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. 

Subunit:
Interacts with dopamine receptor DRD3.xy-1460R    IL-23R白介素-23受體抗體
xy-1434R    IGFBP3胰島素樣生長因子結合蛋白3抗體
xy-1459R    IL-6R Beta/CD130/gp130白細胞介素6受體β抗體IL-6Rβ
xy-1463R    IFNGR1干擾素-gamma受體1抗體
xy-10540R    IL-1 Alpha Propeptide白介素1α前肽/IL-1α前肽抗體
xy-13771R    ITGA11整合素α11抗體
xy-15571R    IGFL2胰島素生長因子樣家族成員2抗體
xy-15540R    IDI2異戊烯基焦磷酸異構酶2抗體
xy-2784R    ITKIL-2誘導型T細胞激酶抗體
xy-15568R    IGF2ASIGF2基因的互補基因1蛋白抗體
xy-15551R    IFI44L干擾素誘導蛋白44樣蛋白抗體
xy-10028R    ITGB4整合素β4抗體
xy-15575R    IGKV A18kappa輕鏈可變區(qū)抗體
xy-2583R    ICOS/CD278誘導協(xié)同刺激分子CD278抗體
xy-2630R    IL-31白細胞介素31抗體
xy-2627R    IL-28A/IFNL2白細胞介素28A抗體
xy-2632R    IL-32/NK4白介素32抗體
xy-2633R    IL-33/NFHEV白介素33抗體
xy-2634R    ILT2/CD85j細胞表面免疫球蛋白樣轉錄因子2抗體
xy-2635R    Integrin alpha 2/CD49b整合素α2抗體
xy-2636R    Integrin alpha 2b/CD41血小板膜糖蛋白ⅡbⅢa抗體
xy-2607R    IL-17RC/IL-17RL白介素17受體C抗體
xy-2584R    IGSF8免疫球蛋超家族成員8抗體
xy-2208R    IL-33白介素33抗體
xy-7715R    Importin 9核蛋白9抗體（Ran結合蛋白M）
xy-3840R    eIF3A真核翻譯起始因子3A抗體
xy-4003R    phospho-eIF4G (ser1185)磷酸化真核翻譯起始因子4G抗體
xy-2055R    Integrin alpha 4+Beta 7整合素α4β7抗體
xy-9278R    phospho-IRF3 (Ser386)磷酸化干擾素調節(jié)因子3抗體
xy-9025R    ISLR2ISLR2蛋白抗體