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嘌呤受體P2X7抗體

英文名稱 P2RX7
中文名稱 嘌呤受體P2X7抗體
別    名 ATP receptor; P2X purinoceptor 7; P2X7; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel 7; P2RX7_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  通道蛋白  細(xì)胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human P2RX7 (115-160aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP.

Function:
The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression.

Subunit:
Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB.xy-9914R    ITIH4α胰蛋白酶重鏈H4抗體
xy-0298R    IGBP1免疫球蛋白結(jié)合蛋白-1抗體
xy-9904R    IGFALS胰島素樣生長因子酸不穩(wěn)定亞基ALS抗體
xym-0862M    Insulin(1D4:)豬胰島素單克隆抗體
xy-2907R    IKK alphaKB抑制蛋白激酶α/IκBα/IKK-α/IKKα/I-κB-α 抗體
xy-0855R    Insulin抗重組人胰島素抗體
xy-3399R    Phospho-INPPL1(Tyr1135)磷酸化肌醇聚磷酸鹽磷酸酶樣蛋白1抗體
xy-0681R    Insulin Receptor胰島素受體抗體
xy-0260R    Insulin Receptor Alpha胰島素受體α抗體
xy-0290R    Insulin Receptor Beta胰島素受體β抗體
xy-7557R    IKK alpha + IKK betaKB抑制蛋白激酶α/β抗體
xy-0767R    IL-12白介素12抗體
xy-9704R    IFI35干擾素誘導(dǎo)35蛋白抗體
xy-9705R    ITM2A完整膜蛋白E25A抗體
xy-0825R    IFABP小腸型脂肪酸結(jié)合蛋白抗體
xy-0018M    IDE胰島素降解酶抗體
xy-2910R    IKK betaKB抑制蛋白激酶β抗體
xy-2608R    IL-17RD白介素17受體D抗體
xy-2609R    IL-17B白介素-17B抗體
xy-0902M    IAA吲哚乙酸/植物生長素單克隆抗體
xy-2458R    IL-4R白細(xì)胞介素4受體抗體IL-4Rα
xy-2545R    IL-2R gamma白介素2受體γ鏈抗體
xy-2594R    IL-1R1白介素1受體1抗體
xy-2595R    IL-1R2白介素1受體2抗體
xy-2619R    IL-20R alpha白介素20受體α鏈抗體
xy-2620R    IL-20RB白介素20受體β鏈抗體
xy-0902R    IAA吲哚乙酸抗體/植物生長素抗體
xy-2641R    Integrin alpha 6整合素α6抗體
xy-0245R    IKI3 family protein擬南芥IKI3抗體
xy-1318R    IL-5白細(xì)胞介素5抗體
xy-6464R    IRAK1白介素-1受體相關(guān)激酶1抗體
xy-0567R    Integrin alpha 5/CD49e/ITGA5整合素α5抗體Integrin α5
xy-0486R    Integrin beta 1整合素β1/Integrin β1抗體
xy-1310R    Integrin Alpha V + Beta 3 (CD51+CD61)整合素αVβ3抗體
xy-1312R    IGF2BP3胰島素樣生長因子2 mRNA 結(jié)合蛋白3抗體