枯草溶菌素轉(zhuǎn)化酶1抑制劑抗體 返回列表頁

枯草溶菌素轉(zhuǎn)化酶1抑制劑抗體

英文名稱 PROSAAS
中文名稱 枯草溶菌素轉(zhuǎn)化酶1抑制劑抗體
別    名 b-LEN; b-PEN-LEN; b-SAAS; Big LEN; granin like neuroendocrine peptide; l-LEN; l-SAAS; N-proSAAS; PCSK1_RAT; Pcsk1n; pro-SAAS; Proprotein convertase 1 inhibitor; Proprotein convertase subtilisin/kexin type 1 inhibitor; PROSAAS; SAAS; SAAS CT(1-49); SAAS CT(25-40).
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  內(nèi)分泌病  泛素  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
細胞定位 細胞漿 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from rat PROSAAS (34-130aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]

Function:
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.

Subunit:
Interacts via the C-terminal inhibitory domain with PCSK1 65 kDa form.xy-13651R    LNK淋巴細胞特異性接頭蛋白抗體
xy-7349R    LILRB2細胞表面免疫球蛋白樣轉(zhuǎn)錄因子4抗體
xy-13652R    LY6G6F淋巴細胞抗原6重復(fù)位點蛋白G6F抗體
xy-13653R    Leupaxin樁蛋白抗體
xy-6055R    LRPAP1脂蛋白受體相關(guān)蛋白/低密度脂蛋白相關(guān)蛋白的相關(guān)蛋白1抗體
xy-6068R    LEPREL2皮屑樣蛋白2抗體
xy-1969R    LAMA3層粘蛋白α3抗體
xy-1970R    LAMP1溶酶體相關(guān)膜蛋白1抗體
xy-1971R    Lxn/Latexin羧肽酶抑制劑抗體
xy-1972R    LCAT卵磷酯膽固醇?；D(zhuǎn)移酶抗體
xy-1973R    LPL/PLASTIN2脂蛋白脂酶抗體
xy-0961R    Leptin receptor瘦素受體抗體
xy-2905R    LRP6低密度脂蛋白受體相關(guān)蛋白6抗體
xy-3253R    Phospho-LRP6 (Ser1490)磷酸化低密度脂蛋白受體相關(guān)蛋白6抗體
xy-3245R    Phospho-LATS1 (Thr1079)磷酸化腫瘤抑制基因LATS1抗體
xy-0683R    LRRK2富亮氨酸重復(fù)激酶2抗體
xy-0661R    LRP肺耐藥相關(guān)蛋白抗體
xy-9329R    LRCH3富含亮氨酸重復(fù)家庭蛋白3抗體
xy-9466R    LRRC10富含亮氨酸重復(fù)蛋白10抗體
xy-9328R    LRCH2富含亮氨酸重復(fù)家庭蛋白2抗體
xy-7615R    LRDD富含亮氨酸重復(fù)死亡結(jié)構(gòu)域蛋白抗體
xy-0901R    LAMR1(CT)層粘連蛋白受體1抗體（C端）
xy-0900R    LAMR1層粘連蛋白受體1抗體（N端）
xy-9842R    phospho-LEF1(Ser42)磷酸化淋巴增強因子-1抗體
xy-11351R    LAP1層粘連相關(guān)多肽蛋白1抗體
xy-11175R    Lubricin淺表層粘膜蛋白多糖抗體
xy-11200R    LHX2調(diào)控胚胎干細胞分化蛋白Lhx2抗體
xy-8360R    LRRC2LRRC2蛋白抗體
xy-11090R    LRRC4B神經(jīng)突觸蛋白NGL3抗體
xy-9972R    LCA5L致盲基因LCA5樣蛋白抗體
xy-9973R    LCA5致盲基因LCA5蛋白抗體
xy-7869R    LHX6轉(zhuǎn)錄因子LHX6抗體
xy-7913R    phospho-LATS1+LATS2 (Thr1079 +Thr1041)磷酸化腫瘤抑制基因LATS1/LATS2抗體
xy-11867R    LBX1轉(zhuǎn)錄因子LBX1抗體
xy-11868R    LDB1神經(jīng)細胞特異性轉(zhuǎn)錄因子LDB1抗體
xy-11869R    LECT2白細胞細胞化學(xué)吸引素2抗體
xy-11870R    LHX5LHX5蛋白抗體
xy-11871R    LIM kinase 1 + 2單絲氨酸蛋白激酶1+2抗體
xy-11872R    LIN7CLIN7C蛋白抗體
xy-11873R    LINGO4富含亮氨酸重復(fù)序列Nogo受體反應(yīng)蛋白4抗體
xy-10536R    LRG1富含亮氨酸α2糖蛋白抗體
xy-11875R    LPPR4腦特異性磷脂酸磷酸酶樣蛋白1抗體