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凋亡誘導(dǎo)受體TNFRSF25抗體

中文名稱(chēng) 凋亡誘導(dǎo)受體TNFRSF25抗體
別    名 Apo 3; Apo-3; Apo3; Apoptosis inducing receptor AIR; Apoptosis inducing receptor; Apoptosis mediating receptor; Apoptosis mediating receptor DR 3; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; DDR 3; DDR3; Death domain receptor 3; Death Receptor 3; Death receptor beta; DR 3; LARD; Lymphocyte associated receptor of death; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; TNFRSF 12; TNFRSF 25; TNFRSF12; TNFRSF25; TNR25_HUMAN; TR 3; TR3; TRAMP; Translocating chain association membrane protein; Tumor necrosis factor receptor superfamily member 12; Tumor necrosis factor receptor superfamily member 25; WSL 1; WSL; WSL LR; WSL protein; WSL1; WSL1 protein; WSLLR.
 
說(shuō) 明 書(shū) 0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
細(xì)胞定位 細(xì)胞膜 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TNFRSF25
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor is expressed preferentiallyin the tissues enriched in lymphocytes, and it may play a role inregulating lymphocyte homeostasis. This receptor has been shown tostimulate NF-kappa B activity and regulate cell apoptosis. Thesignal transduction of this receptor is mediated by various deathdomain containing adaptor proteins. Knockout studies in micesuggested the role of this gene in the removal of self-reactive Tcells in the thymus. Multiple alternatively spliced transcriptvariants of this gene encoding distinct isoforms have beenreported, most of which are potentially secreted molecules. Thealternative splicing of this gene in B and T cells encounters aprogrammed change upon T-cell activation, which predominantlyproduces full-length, membrane bound isoforms, and is thought to beinvolved in controlling lymphocyte proliferation induced by T-cellactivation. [provided by RefSeq, Jul 2008].

Function:
Receptor for TNFSF12/APO3L/TWEAK. Interacts directlywith the adapter TRADD. Mediates activation of NF-kappa-B andinduces apoptosis. May play a role in regulating lymphocytehomeostasis.

Subunit:
Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signalingcascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

Subcellular Location:
Isoform 1, 2, 9, 11: Cell membrane; Single-pass type I membrane protein. 
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xy-3859R    MAGP2纖微絲相關(guān)糖蛋白2抗體
xy-2353R    Mast Cell Chymase肥大細(xì)胞類(lèi)糜蛋白酶1抗體
xym-2059M    Metronidazole(1C2)甲硝唑單克隆抗體
xy-3834R    MrpL12線粒體核糖體蛋白L12抗體
xy-3835R    MrpL39線粒體核糖體蛋白L39
xy-3788R    Mitochondrial Pyruvate dehydrogenase kinase 1丙酮酸脫氫酶激酶1抗體
xy-4138R    MAPK11絲裂原活化的蛋白激酶p38β抗體
xy-5141R    Matrin 3核基質(zhì)蛋白3抗體
xy-7335R    MHC class I組織相容性復(fù)合體蛋白1抗體
xy-8481R    MHC Class II組織相容性復(fù)合體蛋白2抗體
xy-3950R    MLX轉(zhuǎn)化因子樣蛋白4抗體
xy-3952R    MT-ND5NADH復(fù)合體5抗體
xy-9178R    MTM1肌微管素1抗體
xy-9179R    MLF1 髓細(xì)胞性白血病蛋白1抗體
xy-5413R    phospho-MEK1 (Thr386)磷酸化絲裂原活化蛋白激酶1抗體
xy-4107R    MHC Class II組織相容性復(fù)合體2抗體
xy-5329R    Phospho-mTOR (Tyr144)磷酸化雷帕霉素靶蛋白抗體
xy-3823R    MeCP2甲基化CpG結(jié)合蛋白2抗體
xy-5331R    Phospho-mTOR (Thr2446) 磷酸化雷帕霉素靶蛋白抗體
xy-3955R    MT-ND6NADH復(fù)合體6抗體
xy-4718R    MAGEA11黑色素瘤相關(guān)抗原11抗體
xy-6232R    Msx2同源盒基因Msx2抗體
xy-4660R    phospho-MARK4(Ser423)磷酸化絲氨酸/蘇氨酸蛋白激酶MARK4抗體
xy-6507R    MTCBP1膜型基質(zhì)金屬蛋白酶胞質(zhì)尾結(jié)合蛋白1抗體
xy-6124R    p95 NBS1細(xì)胞周期調(diào)節(jié)蛋白P95抗體
xy-4309R    MAP LC3 Beta自噬微管相關(guān)蛋白輕鏈β3抗體
xy-7812R    MPP9有絲分裂細(xì)胞周期蛋白MPP9抗體
xy-7811R    MNS1減數(shù)分裂特異核結(jié)構(gòu)蛋白1抗體
xy-7756R    MyoGEF肌球蛋白相互作用G蛋白交換因子抗體
xy-4684R    Mammaglobin A乳腺珠蛋白1抗體
xy-7031R    MEOX 2間充質(zhì)同源盒蛋白2抗體
xy-6606R    MRGX1G蛋白偶聯(lián)受體MRGX1抗體
xy-6817R    MAGEA11黑色素瘤相關(guān)抗原11抗體
xy-5926R    MAS1LG蛋白偶聯(lián)受體MAS相關(guān)蛋白抗體