蛋白質(zhì)磷酸酶2A-B55抗體 返回列表頁

蛋白質(zhì)磷酸酶2A-B55抗體

英文名稱 PPP2R2B/PP2A-B55
中文名稱 蛋白質(zhì)磷酸酶2A-B55抗體
別    名 2ABB_HUMAN; B55 beta; Beta isoform of regulatory subunit B55 protein phosphatase 2; MGC24888; PP2A B Subunit B Alpha Isoform; PP2A B55beta; PP2A PR55B; PP2A subunit B B beta isoform; PP2A subunit B B55 beta isoform; PP2A subunit B isoform B55 beta; PP2A subunit B isoform B55-beta; PP2A subunit B isoform beta; PP2A subunit B isoform PR55 beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2 beta; PP2A subunit B isoform R2-beta; PP2A subunit B PR55 beta isoform; PP2A subunit B R2 beta isoform; Ppp2r2b; PR2AB beta; PR2AB55 beta; PR2APR55 beta; PR52B; PR55 beta; Protein phosphatase 2 (formerly 2A) regulatory subunit B (PR 52) beta isoform; Protein phosphatase 2 (formerly 2A) regulatory subunit B beta isoform; Protein phosphatase 2 regulatory subunit B; Protein phosphatase 2 regulatory subunit B beta isoform; SCA 12; SCA12; Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; Serine/Threonine Protein Phosphatase 2A 56kDa Regulatory Subunit Alpha Isoform; Serine/threonine protein phosphatase 2A neuronal isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform.
    
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PPP2R2B/PP2A-B55 (51-130aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimay involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2A? and PP2A∫. The PP2A catalytic subunit associates with a variety of regulatory subunits. The B family of regulatory subunits (including B55, B56 and PR72/130 subfamilies) is believed to participate in substrate specificity and catalytic activity. PP2A-B55, also known as PP2A regulatory subunit subfamily B55 or PP2A-B1, is a B subfamily consisting of four B55 isoforms (Alpha,Beta, Gamma and Delta) encoded by four distinct genes.

Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance.

Subunit:
PP2A consists of a common heterodimeric core enzyme,composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDaconstant regulatory subunit (PR65 or subunit A), that associateswith a variety of regulatory subunits. Proteins that associate withthe core dimer include three families of regulatory subunits B (theR2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the48 kDa variable regulatory subunit, viral proteins, and cellsignaling molecules.xy-2967R    Maltose Binding Protein/MBP麥芽糖結(jié)合蛋白抗體
xy-2965R    Myosin-XVIIIb肌球蛋白XVIIIb抗體
xy-4693R    MALMAL蛋白抗體
xy-10238R    Maltoporin麥芽糖孔蛋白抗體
xy-5721R    MBNL3毒蕈堿樣蛋白3抗體
xy-6763R    MSR1巨噬細(xì)胞清道夫受體1抗體
xy-4622R    Mycobacterium bovis牛結(jié)核桿菌菌體蛋白抗體
xy-6844R    MALT淋巴細(xì)胞成熟相關(guān)蛋白抗體
xy-6843R    MAGED1黑色素瘤相關(guān)抗原D1抗體
xy-6839R    MIER2中胚層誘導(dǎo)早期反應(yīng)蛋白2抗體
xy-7663R    MDMXMDM2樣P53蛋白結(jié)合抗體
xy-7616R    MCG10RNA相關(guān)結(jié)合蛋白MCG10抗體
xy-9624R    MRPS4線粒體核糖體蛋白S4抗體
xy-12099R    MUPP1緊密連接蛋白MUPP1抗體
xy-11217R    MTMR14肌管素相關(guān)蛋白14抗體
xy-11227R    Microcephalin 1/BRIT1小腦癥基因1/認(rèn)知相關(guān)蛋白抗體
xy-11234R    Miz1/ZNF60鋅指蛋白60抗體
xy-11264R    MYO6肌球蛋白6抗體
xy-9566R    Musclin肌肉素抗體
xy-12012R    MGLUR3代謝型谷氨酸受體-3抗體
xy-12013R    MGLUR2 + MGLUR3促代謝型谷氨酸受體2+3抗體
xy-12014R    MGLUR1 + MGLUR5促代謝型谷氨酸受體1+5抗體
xy-4899R    MICAMHC I類鏈相關(guān)蛋白A/組織相容性復(fù)合物MHCIa抗體
xy-9389R    MURF2肌肉特異性環(huán)指蛋白2抗體
xy-9390R    MURF3肌肉特異性環(huán)指蛋白3抗體
xy-7919R    phospho-MST1R(Tyr1353) 磷酸化原癌基因c-Met相關(guān)酪氨酸激酶抗體
xy-7920R    MAPK13絲裂原活化蛋白激酶13抗體
xy-12399R    Multicilin多纖毛素蛋白抗體
xy-7936R    MTMR8肌管素相關(guān)蛋白8抗體
xy-6412R    MRC2巨噬細(xì)胞甘露糖受體2抗體
xy-7896R    MNAT1細(xì)胞周期G1的相互作用蛋白抗體
xy-12398R    MAML3主導(dǎo)控制樣蛋白3抗體
xy-1689R    MEK3絲裂原活化蛋白激酶MKK3抗體
xy-2166R    MYSM1MYSM1抗體
xy-1569R    MCT1單羧酸轉(zhuǎn)運(yùn)蛋白-1抗體