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旁瘤抗原MA1抗體

英文名稱 PNMA1
中文名稱 旁瘤抗原MA1抗體
別    名 37 kDa neuronal protein; MA1; Paraneoplastic antigen MA1;

說(shuō) 明 書 0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 40kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PNMA1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Paraneoplastic neurological disorders (PNDs) are rare syndromes that are caused by, or associated with, an underlying neoplasm. The most common neoplasm among young male patients is testicular cancer, but the leading cause among other patients is lung cancer. Most PNDs are caused by an immune response against onconeural antigens, causing progressive neurological damage. The paraneoplastic antigen MA family contains three known members: MA1, MA2 and MA3. MA1, also designated neuron- and testis-specific protein 1, is a nucleolar protein in normal cells but localizes to the cytoplasm of tumor cells. MA2, also designated onconeuronal antigen MA2, is a nucleolar protein expressed in brain and testis. MA3 is highly expressed in brain and testis and is expressed at low levels in heart, trachea and kidney.

Function:
PNMA1 (Paraneoplastic antigen MA1) is a protein that is highly restricted to the brain and testis. A paraneoplastic phenomenon is a disease or symptom that is the consequence of the presence of cancer in the body, but is not due to the local presence of cancer cells. These phenomena are mediated by humoral factors (by hormones or cytokines) excreted by tumor cells or by an immune response against the tumor. Sometimes the symptoms of paraneoplastic syndromes show even before the diagnosis of a malignancy. Paraneoplastic syndromes can be divided into 4 main categories: mucocutane paraneoplastic syndromes, neurological paraneoplastic syndromes, haematological paraneoplastic syndromes and endocrine metabolic syndromes. 

.2ml  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SOX5
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the 轉(zhuǎn)錄因子SOX5抗體
PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Function:
Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.

Subcellular Location:
Nucleus.
xy-11029R    MID2/RNF60/Midline-2環(huán)指蛋白60抗體
xy-9867R    MYL7肌球蛋白輕鏈7抗體
xy-9868R    MYBPC3心臟肌球蛋白結(jié)合蛋白抗體
xy-9610R    MYH9肌球蛋白重鏈9抗體
xy-8562R    MLLT11髓系/淋巴或混合型白血病11抗體
xy-8461R    MX2干擾素誘導(dǎo)GTP結(jié)合蛋白MX2抗體
xy-6454R    BA46乳腺上皮細(xì)胞抗原BA46抗體
xy-0401R    Metal ion transporter擬南介金屬離子轉(zhuǎn)運(yùn)蛋白抗體
xy-0761R    Midnolin中腦核仁蛋白抗體
xy-9862R    MYH7B肌球蛋白重鏈7抗體
xy-9863R    MYOM1肌間蛋白1抗體
xy-9864R    MYOM2肌間蛋白2抗體
xy-9865R    MYLK3肌球蛋白輕鏈激酶3抗體
xy-9866R    MYLK2肌球蛋白輕鏈激酶2抗體
xy-6781R    MAP3K10絲裂原活化蛋白激酶3K10抗體
xy-6782R    MST4絲氨酸/蘇氨酸蛋白激酶MST4抗體
xy-7761R    Myosin VIIa肌球蛋白7a/常染色體隱性耳聾蛋白2抗體
xy-8084R    MBC1膀胱癌突變蛋白1抗體
xy-9376R    MURF3肌肉特定環(huán)指蛋白3抗體
xy-9377R    EDPF1腸細(xì)胞分化相關(guān)因子1抗體
xy-9379R    RNF62環(huán)指蛋白62抗體
xy-6933R    MICBMHC I類鏈相關(guān)蛋白B
xy-7115R    MLC1膜蛋白MLC1抗體
xy-3278R    Phospho-MKP1 (Ser359)磷酸化絲裂原活化蛋白激酶磷酸酶-1抗體
xy-3279R    Phospho-MKP1 (Ser296)磷酸化絲裂原活化蛋白激酶磷酸酶-1抗體
xy-2992R    MLK3絲氨酸/蘇氨酸蛋白激酶MLK3抗體
xy-3280R    Phospho-MLK3(Thr277 + Ser281)磷酸化絲氨酸/蘇氨酸蛋白激酶MLK3抗體
xy-2995R    MSK1有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3281R    Phospho-MSK1 (Ser360)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3282R    Phospho-MSK1 (Ser212)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3283R    Phospho-MSK1 (Ser376)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-3284R    Phospho-MSK1 (Thr581)磷酸化有絲分裂原和應(yīng)激活化型蛋白激酶1抗體
xy-2998R    MYPT1肌球蛋白磷酸酶抗體
xy-3285R    Phospho-MYPT1 (Ser507)磷酸化肌球蛋白磷酸酶抗體
xy-3286R    Phospho-MYPT1 (Ser668)磷酸化肌球蛋白磷酸酶抗體
xy-3287R    Phospho-MYPT1(Thr696)磷酸化肌球蛋白磷酸酶抗體
Similarity:
Contains 1 HMG box DNA-binding domain.

Gene ID:
6660

Database links:

Entrez Gene: 6660 Human

Entrez Gene: 20678 Mouse

Entrez Gene: 140587 Rat

Omim: 604975 Human

SwissProt: P35711 Human

SwissProt: P35710 Mouse

Unigene: 657542 Human轉(zhuǎn)錄因子SOX5抗體xy-5411R    phospho-MEK1 (Ser385)磷酸化絲裂原活化蛋白激酶1抗體
xy-5412R    phospho-MEK1 (Thr292)磷酸化絲裂原活化蛋白激酶1抗體
xy-5414R    phospho-MEK1 + MEK2 (Ser222 + Ser226)磷酸化絲裂原活化蛋白激酶1抗體
xy-2953R    Exportin 1染色體區(qū)域穩(wěn)定蛋白/核輸出蛋白1/染色體區(qū)域穩(wěn)定必需蛋白抗體
xy-5718R    Ensconsin上皮細(xì)胞微管相關(guān)蛋白7抗體
xy-4277R    ENPP7堿性鞘磷脂酶7抗體
xy-7029R    EDIL3表皮生長(zhǎng)因子樣重復(fù)折疊1結(jié)構(gòu)域蛋白3抗體
xy-7055R    ELOVL6長(zhǎng)鏈脂肪酸延長(zhǎng)酶長(zhǎng)ELOVL6抗體
xy-7033R    EphA6酪氨酸蛋白激酶受體A6抗體
xy-7032R    EphA3酪氨酸蛋白激酶受體A3抗體
xy-7034R    EphA7酪氨酸蛋白激酶受體A7抗體
xy-7037R    EphB1酪氨酸蛋白激酶受體B1抗體
xy-10138R    phospho-Eph receptor B1 (Tyr928)磷酸化酪氨酸蛋白激酶受體B1抗體
xy-10139R    phospho-EphB1/Eph receptor B1(Tyr968)磷酸化酪氨酸蛋白激酶受體B1抗體
xy-13060R    EFS對(duì)接蛋白EFS抗體
xy-6599R    Eph receptor A5酪氨酸蛋白激酶A5受體抗體
xy-11457R    EDG8內(nèi)皮細(xì)胞分化G蛋白偶聯(lián)受體8抗體
xy-11458R    Ephexin-1神經(jīng)細(xì)胞鳥苷酸置換因子NGEF抗體
xy-4842R    Phospho-eIF2 alpha(Ser51)磷酸化真核啟動(dòng)因子2α抗體
xy-7053R    ELOVL2長(zhǎng)鏈脂肪酸延長(zhǎng)酶ELOVL2抗體
xy-7054R    ELOVL5長(zhǎng)鏈脂肪酸延長(zhǎng)酶長(zhǎng)ELOVL5抗體
xy-11838R    Emx1有脊椎動(dòng)物腦發(fā)育相關(guān)蛋白Emx1抗體
xy-8043R    ENC1外胚層神經(jīng)皮層蛋白1抗體
xy-13070R    ENOSF1烯醇化酶超家族成員1抗體
xy-4913R    ENPP1核苷酸內(nèi)焦磷酸酶/磷酸二酯酶1抗體
xy-9506R    EPCR內(nèi)皮細(xì)胞活化蛋白受體抗體
xy-9507R    EPR1效應(yīng)細(xì)胞蛋白酶受體1抗體
xy-11250R    EEA1早期內(nèi)吞體相關(guān)蛋白1抗體
xy-11251R    EPS15胞吞調(diào)控蛋白Eps15抗體
xy-4979R    eIF4E真核翻譯起始因子4E抗體
xy-11219R    Exportin 5核輸出蛋白5抗體
xy-0659R    E.coli腸致病性大腸桿菌抗體