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大腦蛋白1抗體

英文名稱 POU3F3
中文名稱 大腦蛋白1抗體
別    名 Brain 1; Brain1; Brain specific homeobox/POU domain protein 1; Brain-1; Brain-specific homeobox/POU domain protein 1; Brain1; BRN 1; Brn-1; BRN1; class 3; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF 8; OTF-8; OTF8; PO3 F3; PO3F 3; PO3F3; PO3F3_HUMAN; POU class 3 homeobox 3; POU domain; POU domain, class 3, transcription factor 3; POU3 F3; POU3F 3; Pou3f3; RHS 1; Rhs 2; RHS1; Rhs2; Skin 1; Skin1; transcription factor 3.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Brain1/POU3F3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU domain proteins. Expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons, Brn-1 and Brn-2 appear to critically control the initiation of radial migration of cortical neurons. Brn-2 is thought to be involved in smooth muscle cell development and differentiation. Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. Brn-3a has two functional transactivating domains, one at the amino terminus and one at the carboxy terminus. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor.

Function:
Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3').

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain.

Similarity:
Belongs to the POU transcription factor family. Class-3 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.

Database links:

Entrez Gene: 5455 Human

Entrez Gene: 18993 Mouse

Entrez Gene: 192109 Ratxy-3288R    Phospho-MYPT1 (Thr853)磷酸化肌球蛋白磷酸酶抗體
xy-3273R    Phospho-Met (Tyr1349)磷酸化肝細(xì)胞生長因子受體(原癌基因)抗體
xy-2911R    MEK6絲裂原活化蛋白激酶MKK6抗體
xy-3274R    Phospho-MKK3(Ser218) + MKK6(Ser207) 磷酸化絲裂原活化蛋白激酶MKK3/6抗體
xy-3275R    Phospho-MEK6 (Ser207)磷酸化絲裂原活化蛋白激酶MKK6抗體
xy-1761R    MDC嗜酸粒細(xì)胞趨化蛋白22抗體
xy-1759R    Met Enkephalin甲硫氨酸腦啡肽抗體
xy-2129R    Morphine嗎啡抗體
xy-2099R    MMP-9基質(zhì)金屬蛋白酶9抗體
xy-1882R    MRas原癌基因M-ras抗體
xy-1955R    MCP1單核細(xì)胞趨化蛋白1抗體
xy-2029R    Morphine嗎啡抗體
xy-1676R    MG雞毒支原體抗體
xy-8520R    MtTF1線粒體轉(zhuǎn)錄因子1抗體
xy-1595R    MAD1有絲分裂抑制缺陷蛋白1抗體
xy-9344R    MARCH10膜相關(guān)環(huán)指蛋白10抗體
xy-6863R    MALT1粘膜相關(guān)淋巴組織淋巴瘤轉(zhuǎn)運(yùn)蛋白1抗體
xy-0642R    MAdCAM-1粘膜血管定居因子抗體
xy-0792R    Maspin抑癌基因抗體
xy-0671R    MCK10神經(jīng)上皮酪氨酸激酶/乳腺癌激酶10抗體
xy-0832R    MICAMHC I類鏈相關(guān)蛋白A/組織相容性復(fù)合物MHCIa抗體
xy-0762R    Midnolin中腦核仁蛋白抗體
xy-1044R    MIF巨噬細(xì)胞移動(dòng)抑制因子抗體
xy-1045R    CCL3巨噬細(xì)胞炎癥因子1α抗體 MIP-1α
xy-1150R    muscarinic Acetylcholine Receptor 1毒蕈堿型乙酰膽堿受體M1抗體
xy-0257R    MAG髓鞘相關(guān)糖蛋白a/b抗體
xy-1041R    MEK1 + MEK2絲裂原活化蛋白激酶激酶1抗體
xy-0223R    MEK2絲裂原活化蛋白激酶激酶2抗體
xy-0531R    Matriptase蛋白裂解酶（一種新的癌基因）抗體
xy-0380R    MBP髓鞘堿性蛋白/磷脂堿性蛋白抗體
xy-0051R    MelanA黑色素瘤相關(guān)抗原/黑色素-A抗體
xy-1101R    MCP1單核細(xì)胞趨化蛋白1抗體
xy-1042R    MCSF巨噬細(xì)胞克隆刺激因子抗體
xy-1043R    MDM2雙微體2癌基因抗體