神經(jīng)特異蛋白酪氨酸磷酸酶N5抗體 返回列表頁

神經(jīng)特異蛋白酪氨酸磷酸酶N5抗體

英文名稱 PTPN5/STEP
中文名稱 神經(jīng)特異蛋白酪氨酸磷酸酶N5抗體
別    名 Neural specific protein tyrosine phosphatase; Neural-specific protein-tyrosine phosphatase; Protein tyrosine phosphatase non receptor type 5 (striatum enriched); Protein tyrosine phosphatase non receptor type 5; Protein tyrosine phosphatase striatum enriched; PTN5; PTN5_HUMAN; PTP STEP; PTPN 5; Ptpn5; PTPSTEP; STEP; Striatum-enriched protein-tyrosine phosphatase; Tyrosine protein phosphatase non receptor type 5; Tyrosine-protein phosphatase non-receptor type 5; FLJ14427.
 
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPN5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The brain-specific STEP (striatal enriched phosphatase) family of protein tyrosine phosphatases (PTPs) comprises both transmembrane and cytosolic protein members which are the products of alternative splicing. STEP family members are expressed in the dopaminoceptive neurons of the CNS, with highest expression in the basal ganglia and related structures. The STEP protein regulates the N-methyl-d-aspartate receptor (NMDAR) complex; STEP depresses both NMDAR single-channel activity and synaptic currents. The membrane-associated STEP61 isoform localizes in the postsynaptic densities (PSDs) of striatal neurons. STEP61 contains a single tyrosine phosphatase domain, two proline-rich domains and two transmembrane domains. The STEP61 protein associates with the Src family kinase member Fyn when Fyn is phosphorylated at Tyr-420 and not Tyr-431. Upon association, STEP61 dephosphorylates Tyr-420 residue and may thus regulate Fyn activity in PSDs. Isolated from mouse brain, the STEP20 isoform lacks the conserved tyrosine phosphatase domain. The human STEP gene maps to chromosome 11p15.2-p15.1.

Function:
May regulates the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.xy-6704R    NEDD5神經(jīng)前體細(xì)胞表達發(fā)育下調(diào)蛋白5抗體
xy-6711R    Netrin 4軸突生長誘向因子4抗體
xy-11594R    Nicalinγ-分泌酶組件蛋白NCLN抗體
xy-11572R    NR2E3核受體蛋白NR2E3抗體
xy-7815R    NEK8絲氨酸/蘇氨酸蛋白激酶NEK8抗體
xy-7819R    NUP37核孔蛋白Nup37抗體
xy-7816R    NSP5核結(jié)構(gòu)蛋白5抗體
xy-7817R    NUBP1核苷酸結(jié)合蛋白1抗體
xy-7818R    NUBP2核苷酸結(jié)合蛋白2抗體
xy-7757R    NAT10乙?；D(zhuǎn)移酶10抗體
xy-7758R    NEK7絲氨酸/蘇氨酸蛋白激酶Nek7抗體
xy-4142R    NPTX1神經(jīng)細(xì)胞正五聚體1抗體
xy-5097R    NNT煙酰胺核苷酸轉(zhuǎn)氫酶抗體
xy-2348R    Natriuretic Peptide Receptor B利鈉肽受體B抗體
xy-2333R    NPRC利鈉肽受體C抗體
xy-5381R    Phospho-NMDAR2B (Tyr1336)磷酸化谷氨酸受體2B抗體
xy-5380R    Phospho-NMDAR2B (Tyr1252)磷酸化谷氨酸受體2B抗體
xy-3889R    NOX2NADPH氧化酶2抗體
xy-3891R    NOXA2NADPH氧化酶活化蛋白1抗體
xy-5660R    phospho-NFKB p65(Ser529)磷酸化細(xì)胞核因子抗體
xy-5661R    phospho-NFKB p65(Thr435)磷酸化細(xì)胞核因子抗體
xy-5662R    phospho-NFKB p65(Thr254)磷酸化細(xì)胞核因子抗體
xy-5663R    phospho-NFKB p65(Thr505)磷酸化細(xì)胞核因子抗體
xy-6167R    NET1神經(jīng)上皮細(xì)胞轉(zhuǎn)化基因1抗體
xy-6181R    Nectin 3 細(xì)胞粘附分子3抗體（脊髓灰質(zhì)炎病毒受體相關(guān)蛋白3）
xy-11524R    NHLH2螺旋環(huán)螺旋蛋白2抗體
xy-12243R    Nodal胚胎發(fā)育相關(guān)蛋白Nodal抗體
xy-12272R    NA生殖細(xì)胞增殖相關(guān)蛋白NA抗體
xy-12273R    NOBOX同源盒蛋白NOBOX抗體
xy-12247R    NAC1轉(zhuǎn)錄因子NAC1抗體
xy-7122R    NGFR神經(jīng)生長因子受體抗體
xy-5517R    phospho-IKB epsilon (Ser157)磷酸化KB抑制蛋白激酶ε
xy-5519R    phospho-NRP1(Thr916)磷酸化神經(jīng)纖毛蛋白1抗體