PHD指蛋白21A抗體 返回列表頁

PHD指蛋白21A抗體

英文名稱 PHF21A
中文名稱 PHD指蛋白21A抗體
別    名 BHC80 / PHF21A; BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35-HDAC complex protein BHC80; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa); KIAA1696; PF21A_HUMAN; PHD finger protein 21A; PHF21A.

說 明 書 0.2ml  
研究領(lǐng)域 神經(jīng)生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 75kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PHF21A (351-450aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]

Function:
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.

Subunit:
Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, KDM1A and RCOR1/CoREST.

Subcellular Location:
Nucleus.xy-10402R    phospho-NIFK (Thr238)磷酸化NIFK抗體
xy-10401R    phospho-NIFK (Thr230)磷酸化NIFK抗體
xy-13693R    NCKAP5NCKAP5蛋白抗體
xy-13694R    NOSTRIN一氧化氮合酶轉(zhuǎn)運(yùn)誘導(dǎo)抗體
xy-13656R    NSMAF中性鞘磷脂相關(guān)因子抗體
xy-15592R    NFIL3人白介素3介導(dǎo)核因子抗體
xy-13657R    NSP3SH2結(jié)構(gòu)域蛋白3A抗體
xy-2464R    Neuritin轉(zhuǎn)化神經(jīng)突起蛋白抗體
xy-13765R    NPIP-like protein 1NPIP樣蛋白1抗體
xy-6058R    Nicastrin老年性癡呆蛋白APH2抗體
xy-6060R    NARC1神經(jīng)細(xì)胞凋亡調(diào)節(jié)轉(zhuǎn)化蛋白1抗體（前蛋白轉(zhuǎn)化酶枯草溶菌素9）
xy-12018R    NPFF1 ReceptorG蛋白偶聯(lián)受體147抗體
xy-3513R    Nur77孤兒核受體蛋白Nur77抗體
xy-3313R    Phospho-Nur77(Ser351)磷酸化孤兒核受體蛋白Nur77抗體
xy-0452R    NAIF1 protein核凋亡誘導(dǎo)因子蛋白1
xy-1067R    NMDAR2C谷氨酸受體2C抗體
xy-0175R    TrkB酪氨酸激酶B抗體
xy-1091R    NADPH oxidase 4NADPH氧化酶4抗體
xy-9316R    NDE1核分布基因E同源蛋白1抗體
xy-9317R    NEK9絲氨酸/蘇氨酸蛋白激酶NEK9抗體
xy-9318R    phospho-NEK9(Thr210)磷酸化絲氨酸/蘇氨酸蛋白激酶NEK9抗體
xy-9319R    NNF1R多胺調(diào)控因子1抗體
xy-9300R    NNP1新型核蛋白質(zhì)1抗體
xy-7080R    Nucleolar protein 3核仁蛋白3抗體
xy-9625R    NPAP1核孔蛋白1抗體
xy-4730R    NADPH oxidase 4NADPH氧化酶4抗體
xy-9713R    FAD24脂肪細(xì)胞分化因子24
xy-9468R    Nebulette肌動蛋白結(jié)合蛋白Z盤狀蛋白抗體
xy-9473R    NFAT5活化T細(xì)胞核因子5蛋白抗體
xy-9474R    phospho-NFAT5 (Ser1197)磷酸化活化T細(xì)胞核因子5蛋白抗體
xy-1373R    Lipocalin 2脂質(zhì)運(yùn)載蛋白抗體
xy-1366R    NF22型神經(jīng)纖維瘤抗體