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磷酸二酯酶7抗體

英文名稱 PDE7A
中文名稱 磷酸二酯酶7抗體
別    名 HCP 1; HCP1; High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A; High affinity cAMP-specific 3''; P2A; PDE 7; PDE 7A; PDE7; PDE71; PDE7A; PDE7A_HUMAN; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; Phosphodiesterase7A; Rolipram insensitive phosphodiesterase type 7; TM 22; TM22; 5''-cyclic phosphodiesterase 7A.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PDE7A (341-440aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Phosphodiesterases (PDE, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP. Phosphodiesterase type 3 isoforms, PDE3A and 3B, are expressed primarily in cardiovascular tissue and adipose tissue, respectively. PDE3A, is found in myocardium and plaets and PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation.

Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Subunit:
Interacts with CBFA2T3.

Subcellular Location:
Cytoplasmxy-8513R    NIR1膜相關(guān)磷脂轉(zhuǎn)運(yùn)蛋白抗體
xy-0903R    Natrexone納曲酮抗體IgG
xy-3297R    Phospho-NDRG1 (Ser330)磷酸化分化相關(guān)基因NDRG1抗體
xy-3298R    Phospho-NDRG1 (Thr346)磷酸化分化相關(guān)基因NDRG1抗體
xy-3506R    NEDD4L泛素連接酶NEDD4-2抗體
xy-3291R    Phospho-NF2(Ser518)磷酸化2型神經(jīng)纖維瘤抗體
xy-3302R    Phospho-NMDAR1(Ser896)磷酸化谷氨酸受體1抗體
xy-3903R    Phospho-NMDAR1 (Ser897)磷酸化谷氨酸受體1抗體
xy-11214R    Nfasc186 神經(jīng)束蛋白186抗體
xy-3299R    Phospho-NEDD4L (Ser342)磷酸化泛素連接酶NEDD4-2抗體
xy-3300R    Phospho-NFKB1 (Ser927)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-3301R    Phospho-NMDAR1 (Ser890)磷酸化谷氨酸受體1抗體
xy-3561R    KAT13C類固醇受體激活蛋白2抗體
xy-0829R    Nanog胚胎干細(xì)胞關(guān)鍵蛋白抗體
xy-1052R    NAP1L1核小體組裝蛋白1抗體
xy-1172R    N-cadherinN-鈣粘附分子抗體
xy-0224R    NCoR1核受體輔助抑制因子1抗體
xy-0513R    Nephrin腎小球細(xì)胞粘附分子受體抗體
xy-0006R    Nestin巢蛋白/神經(jīng)上皮干細(xì)胞蛋白抗體
xy-0008R    Nestin巢蛋白/神經(jīng)上皮干細(xì)胞蛋白抗體
xy-0268R    Neurobeachin蛋白激酶錨定蛋白抗體
xy-11317R    Neuroserpin絲氨酸或半胱氨酸蛋白水解酶抑制蛋白1抗體
xy-4800R    NG2黑色素瘤硫酸軟骨素蛋白多糖抗體
xy-11181R    Neuroligin 3突觸細(xì)胞粘附分子3抗體
xy-11323R    Neuroglycan C跨膜硫酸軟骨素蛋白聚糖C抗體
xy-11324R    Nova1神經(jīng)腫瘤Nova1抗原抗體
xy-9558R    NTALB淋巴細(xì)胞鏈接激活蛋白抗體
xy-11193R    NSMase2中性鞘磷脂2抗體
xy-11202R    NR2E1核受體蛋白NR2E1抗體
xy-11171R    NXPH2神經(jīng)外營養(yǎng)蛋白2抗體