PUM1蛋白抗體 返回列表頁

PUM1蛋白抗體

英文名稱 Pumilio 1
中文名稱 PUM1蛋白抗體
別    名 HSPUM; KIAA0099; PUM 1; PUM L1; PUM1; PUM1_HUMAN; PUMH 1; PUMH; PUMH1; Pumilio homolog 1; Pumilio-1; Pumilio1; PUML 1; PUML1.
 
說 明 書 0.2ml  
研究領(lǐng)域 發(fā)育生物學(xué)  干細(xì)胞  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 126kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pumilio 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Pumilio 1, also known as PUM1, PUMH1 (Pumilio homolog 1), HSPUM, PUMH or PUML1, is a homolog of the Drosophila Pumilio protein and belongs to the PUF family. The PUF family is comprised of evolutionarily conserved proteins that contain a C-terminal RNA binding domain made up of eight highly conserved tandem repeats. PUF proteins function as sequence-specific RNA-binding proteins and bind NREs (nanos response elements) in the 3’-untranslated regions of target mRNAs. They play an important role mediating mRNA stabilization and repressing translation. Pumilio 1 is a typical PUF protein expressed in fetal tissues as well as adult stomach, kidney, intestine, muscle, brain and heart tissues. Pumilio 1 localizes to the cytoplasm and is believed to participate in cell fate, cell development, cell differentiation and maintenance of somatic stem cells.

Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity). 

Subunit:
Binds in a sequence-specific manner to the 3'-UTR of some mRNAs. 

Subcellular Location:
Cytoplasm (Probable). 

Tissue Specificity:
Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.

Similarity:
Contains 1 PUM-HD domain. 
Contains 8 pumilio repeats. xy-11115R    PCDHA1原鈣粘附蛋白α1抗體
xy-11117R    PCDHA3原鈣粘附蛋白α3抗體
xy-11118R    PCDHA4原鈣粘附蛋白α4抗體
xy-11119R    PCDHA5原鈣粘附蛋白α5抗體
xy-11120R    PCDHA9原鈣粘附蛋白α9抗體
xy-11121R    PCDHA7原鈣粘附蛋白α7抗體
xy-11122R    PCDHA8原鈣粘附蛋白α8抗體
xy-6285R    PRSS10絲氨酸蛋白酶10抗體
xy-5825R    PCDHA12原鈣粘蛋白12抗體
xy-6293R    Prostatic Acid Phosphatase前列腺酸性磷酸酶抗體
xy-5733R    PAR6缺陷性分配同源物α抗體
xy-5826R    PCDHAC1原鈣粘蛋白1抗體
xy-5814R    Prominin 2造血干細(xì)胞抗原CD133相關(guān)蛋白抗體
xy-6266R    PTK6酪氨酸蛋白激酶6/乳腺腫瘤激酶抗體
xy-5734R    PCGF1表觀抑制因子Polycomb家族成員PCGFl蛋白抗體
xy-11133R    PCDHAC2原鈣粘蛋白介導(dǎo)的PCDHαC2受體抗體
xy-3517M    PAK4小鼠抗p21激活激酶4抗體
xy-7534R    PGC1 beta過氧化物酶體增殖物激活受體γ輔激活子1β抗體
xy-7535R    PGC1 alpha + beta過氧化物酶體增殖物激活受體γ輔激活子1α+β抗體
xy-11788R    Prion protein PrP/CD230朊病毒蛋白CD230抗體
xy-11410R    Progestin Receptor Beta孕激素受體β（MPRβ）抗體
xy-11411R    PTGFR前列腺素F2a受體抗體PGF2αR
xy-6350R    pan methyl Lysine泛甲基賴氨酸抗體
xy-6370R    p70 S6 kinase alpha核糖體p70 S6蛋白激酶抗體
xy-7094R    p53AIP1p53調(diào)節(jié)凋亡誘導(dǎo)蛋白1抗體
xy-7101R    PTRH2Bcl-2轉(zhuǎn)錄抑制因子1抗體
xy-7099R    PLSCR3磷脂爬行酶3抗體
xy-7634R    PARL骨骼肌細(xì)胞線粒體膜蛋白PARL抗體
xy-7100R    PNPT1多核苷酸磷酸化酶蛋白抗體
xy-6382R    PTK5胃腸道相關(guān)酪氨酸激酶抗體（蛋白酪氨酸激酶5）
xy-6392R    PCNPPEST含核蛋白抗體
xy-3020R    phospho-p53BP1 (Ser25 + Ser29)磷酸化p53結(jié)合蛋白1抗體
xy-3756R    PP1A蛋白磷酸酶2Cα抗體