PDZ結(jié)構(gòu)域蛋白GOPC抗體 返回列表頁

PDZ結(jié)構(gòu)域蛋白GOPC抗體

英文名稱 PIST
中文名稱 PDZ結(jié)構(gòu)域蛋白GOPC抗體
別    名 CAL; GOPC; CFTR associated ligand; CFTR-associated ligand; FIG; Fused in glioblastoma; Golgi associated PDZ and coiled coil motif containing; Golgi associated PDZ and coiled coil motif containing protein; Golgi-associated PDZ and coiled-coil motif-containing protein; GOPC_HUMAN; GOPC1; OTTHUMP00000040403; PDZ protein interacting specifically with TC 10; PDZ protein interacting specifically with TC10; PDZ/coiled coil domain binding partner for the rho family GTPase TC 10; PDZ/coiled coil domain binding partner for the rho family GTPase TC10; PIST; Protein interacting specifically with Tc 10; Protein interacting specifically with Tc10; dJ94G16.2; dJ94G16.2 PIST.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PIST
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
PIST (PDZ protein interacting specifically with TC10), also known as GOPC (golgi associated PDZ and coiled-coil motif containing), CAL or FIG, is a 462 amino acid protein that localizes to the cytoplasm, as well as to the membrane of the golgi apparatus and to the cell junction. Expressed ubiquitously and containing one PDZ (DHR) domain, PIST functions as a homooligomer that interacts with a variety of proteins and plays a role in intracellular protein trafficking and degradation. Additionally, PIST is thought to regulate ionic currents via membrane channel modification and may also play a role in autophagy. Chromosomal aberrations in the gene encoding PIST are found in glioblastoma multiform (GBM), a common and aggressive form of brain tumor, suggesting a role for mutated PIST in carcinogenesis. Three isoforms of PIST exist due to alternative splicing events.

Function:
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.xy-5578R    phospho-PTPN6(Ser591)磷酸化蛋白酪氨酸磷酸酶1C抗體
xy-4159R    PI 3 Kinase Class 3磷脂酰肌醇激酶3催化亞單位3抗體
xy-5580R    phospho-PIK3C3(Ser676)磷酸化磷脂酰肌醇激酶3催化亞單位3抗體
xy-5581R    phospho-PIK3C3(Ser164)磷酸化磷脂酰肌醇激酶3催化亞單位3抗體
xy-5585R    phospho-PRKCQ(Thr538)磷酸化蛋白激酶C theta抗體
xy-4160R    PI 3 Kinase p85 beta磷脂酰肌醇激酶p85β抗體
xy-5582R    phospho-PIK3R2(Tyr467)磷酸化磷脂酰肌醇激酶p85β抗體
xy-5586R    phospho-PPM1A(Ser375)磷酸化蛋白磷酸酶2C亞型α抗體
xy-4065R    P2X2三磷酸腺苷受體受體P2X2抗體
xy-10026R    Phospho-Paxillin(Ser83)磷酸化樁蛋白Paxillin抗體
xy-10092R    PLAG1多型性腺瘤基因1蛋白抗體
xy-10235R    Pokemon/ZBTB7蒙蛋白抗體
xy-10564R    Protein CASPCASP抗體
xy-10305R    PIM1+PIM3絲氨酸/蘇氨酸激酶蛋白PIM1+PIM3抗體
xy-13659R    PACSIN3胞漿蛋白PACSIN3抗體
xy-13695R    PAG1跨膜接頭蛋白PAG抗體
xy-13696R    PARD6GPARD6G蛋白抗體
xy-13697R    PL6胎盤蛋白6抗體
xy-13675R    PIK3AP1磷酸肌醇3激酶接頭蛋白1抗體
xy-12676R    PRAM1PRAM1蛋白抗體
xy-10403R    Pan Cytokeratin/p-CK廣譜細(xì)胞角蛋白PCK抗體
xy-10157R    PDZ RHOGEF/GTRAP48Rho鳥甘酸轉(zhuǎn)運蛋白抗體
xy-5538R    phospho-PIK3R1(Tyr368)磷酸化磷脂酰肌醇激酶抗體
xy-5552R    phospho-PARK2(Ser101)磷酸化帕金蛋白抗體
xy-5553R    phospho-PARK2(Ser378)磷酸化帕金蛋白抗體
xy-5554R    Phospho-PDGF Receptor beta (Tyr579)磷酸化血小板源性生長因子受體B抗體
xy-5555R    Phospho-PDGF Receptor beta (Tyr716)磷酸化血小板源性生長因子受體B抗體
xy-4153R    PAK6P21蛋白激活的蛋白激酶6抗體
xy-5556R    phospho-PAK6(Ser165)磷酸化P21蛋白激活的蛋白激酶6
xy-4154R    PTPRA酪氨酸磷酸酶α抗體
xy-4155R    PTPN7非受體型蛋白酪氨酸磷酸酶7抗體
xy-5557R    phospho-PTPN7 (Ser246)磷酸化非受體型蛋白酪氨酸磷酸酶7