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早期發(fā)育調(diào)控蛋白2/HDC2抗體

英文名稱 PHC2
中文名稱 早期發(fā)育調(diào)控蛋白2/HDC2抗體
別    名 HDC2; Early development regulatory protein 2; hPH2; early development regulator 2 (homolog of polyhomeotic 2); early development regulator 2 like; EDR2; MGC163502; mph2; PH2; PHC2; PHC2_HUMAN; polyhomeotic 2; polyhomeotic like 2; Polyhomeotic-like protein 2.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 91kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDC2/PHC2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Subunit:
Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 FCS-type zinc finger. 
Contains 1 SAM (sterile alpha motif) domain. 

Database links:

Entrez Gene: 1912 Human

Entrez Gene: 54383 Mouse

Entrez Gene: 313038 Rat

GenBank: NP_004418.2 Humanxy-5558R    phospho-PTPN7 (Ser93)磷酸化非受體型蛋白酪氨酸磷酸酶7抗體
xy-5559R    phospho-PKC delta (Ser645)磷酸化蛋白激酶C亞性D型抗體
xy-4156R    PKC mu蛋白激酶C mu型抗體
xy-1704R    PAI-1纖溶酶原激活物抑制因子抗體
xy-1551R    Pepsinogen II胃蛋白酶原C抗體
xy-5562R    phospho-PRKD1(Ser742)磷酸化蛋白激酶C mu型抗體
xy-1556R    Profilin 1前纖維蛋白1抗體
xy-2006R    PCNA-Proliferation Marker增殖細(xì)胞核抗原抗體
xy-5540R    phospho-FAK(Tyr925)磷酸化粘著斑激酶抗體
xy-5541R    phospho-PTK2(Tyr576+Tyr577)磷酸化粘著斑激酶抗體
xy-5542R    phospho-PAK1(Thr212)磷酸化p21激活激酶1抗體
xy-5543R    Phospho-PDPK1(Tyr9)磷酸化3磷酸肌醇依賴性蛋白激酶1抗體
xy-5544R    Phospho-PDPK1(Ser396)磷酸化3磷酸肌醇依賴性蛋白激酶1抗體
xy-5545R    Phospho-PDPK1(Ser410)磷酸化3磷酸肌醇依賴性蛋白激酶1抗體
xy-5546R    Phospho-PLC gamma 1(Tyr775)磷酸化磷酯酶Cγ1抗體
xy-5547R    Phospho-PLC gamma 2(Tyr753)磷酸化磷酯酶Cγ2抗體
xy-5548R    Phospho-Paxillin(Tyr88)磷酸化樁蛋白Paxillin抗體
xy-5549R    Phospho-Paxillin(Ser83)磷酸化樁蛋白Paxillin抗體
xy-5550R    Phospho-Paxillin(Ser178)磷酸化樁蛋白Paxillin抗體
xy-2718R    phospho-PKC beta 1/2(Thr500)磷酸化蛋白激酶C β1/β2(Thr500)抗體
xy-5922R    PGRMC孕激素受體膜相關(guān)元件抗體
xy-3714R    Phospho-p63 (Ser395)磷酸化P63腫瘤抑制基因抗體
xy-3715R    Phospho-p63 (Ser455)磷酸化P63腫瘤抑制基因抗體
xy-5952R    POMT1蛋白甘露糖基轉(zhuǎn)移酶1抗體
xy-3497R    Phospho-p40phox (Thr154)磷酸化嗜中性粒細(xì)胞胞漿因子4抗體
xy-3617R    P70 Beta 2核糖體S6蛋白激酶β2抗體
xy-3498R    Phospho-p70 S6 Kinase Beta 2 (Tyr389)磷酸化核糖體S6蛋白激酶β2抗體
xy-3499R    Phospho-p70 S6 Kinase Beta (Thr228)磷酸化核糖體S6蛋白激酶β2抗體
xy-3700R    Phospho-p70 S6 Kinase Beta (Thr444 + Ser447)磷酸化核糖體S6蛋白激酶β2抗體
xy-3701R    phospho-P70 S6 Kinase beta 2 (Ser370)磷酸化核糖體S6K2蛋白激酶抗體
xy-3702R    phospho-P53(Ser15)磷酸化腫瘤抑制基因P53抗體
xy-3703R    phospho-P53(Ser20)磷酸化腫瘤抑制基因P53抗體
xy-3706R    phospho-P53(Ser37)磷酸化腫瘤抑制基因P53抗體
xy-3707R    phospho-P53(Ser46)磷酸化腫瘤抑制基因P53抗體
xy-3708R    phospho-P53(Ser6)磷酸化腫瘤抑制基因P53抗體