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睪丸特異性核苷酸果糖β抗體

英文名稱 PAPOLB
中文名稱 睪丸特異性核苷酸果糖β抗體
別    名 PAP beta; PAP-beta; PAPT; poly(A) polymerase beta (testis specific); poly(A) polymerase beta; polynucleotide adenylyltransferase beta; TPAP.
 
說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 72kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PAPOLB
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-Beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-Beta plays a critical role in male germ cell production. PAP-Beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-∫ maps to chromosome 7p22.3.

Function:
RelevanceThe function of this protein remains unknown. This gene is a member of the myotubularin family and encodes a putative tyrosine phosphatase. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Multiple alternatively spliced transcript variants have been found for this gene, but the protein products of some of these variants are likely not viable, as they are nonsense-mediated mRNA decay (NMD) candidates. xy-0281R    PLGF胎盤生長因子抗體
xy-0280R    PLGF胎盤生長因子抗體
xy-0235R    PMP22外周髓鞘蛋白-22抗體
xy-1048R    Podoplanin平足蛋白抗體(淋巴管內(nèi)皮細(xì)胞蛋白)
xy-0133M    PP-1B蛋白磷酸酯酶-1B抗體
xy-0029R    PP2A alpha + beta蛋白質(zhì)磷酸酶-2A抗體
xy-0490R    PPP4C磷酸酯酶-2Ac抗體
xy-0636R    Phospho-P38 MAPK (Thr180 + Tyr182)磷酸化-絲裂原活化蛋白激酶p38抗體（P-p38 MAPK）
xy-0250R    PPAR delta + betaD型-過氧化酶活化增生受體抗體
xy-0530R    PPAR gamma過氧化酶活化增生受體γ抗體（PPARγ）
xy-0111R    progesterone receptor孕激素受體抗體
xy-0532R    PHD3脯氨酸羥化酶抗體
xy-0024R    presenilin 1早老素蛋白-1抗體
xy-0025M    presenilin 1早老素蛋白-1抗體
xy-0024M    presenilin 1早老素蛋白-1抗體
xy-0669R    PSCA前列腺干細(xì)胞抗原抗體
xy-0179R    PSD95突觸后密度蛋白95抗體
xy-0561R    P-selectin/CD62pP選擇素抗體
xy-0748R    PTEN一種腫瘤抑制基因抗體（N端）
xy-1115R    AMPK alpha-1腺苷單磷酸活化蛋白激酶α1/AMPK α 1抗體
xy-0040R    protein C維生素K依賴的蛋白C重鏈抗體
xy-2692R    Plexin A1神經(jīng)叢蛋白A1抗體
xy-3517R    PAK4p21激活激酶4抗體
xy-3314R    Phospho-PAK4(Ser474) + PAK5(Ser602) + PAK6(Ser560)磷酸化p21激活激酶4/5/6抗體
xy-3315R    Phospho-PAK1(Ser199 + Ser204) + PAK2 (Ser192 + Ser197)磷酸化p21激活激酶1/2抗體
xy-3316R    Phospho-PAK1 + PAK2 + PAK3 (T423 + T402 + T421)磷酸化p21激活激酶1/2抗體
xy-3317R    Phospho-PAK2 (Ser20)磷酸化p21激活激酶2抗體
xy-3532R    PLCG 2磷酯酶Cγ2抗體
xy-3318R    Phospho-PDGFRA(Tyr1018)磷酸化血小板源性生長因子受體-α抗體
xy-3319R    Phospho-PDGFRA(Tyr754)磷酸化血小板源性生長因子受體-α抗體
xy-1346R    P73 proteinP73腫瘤抑制基因抗體
xy-4958R    PCGF1表觀抑制因子Polycomb家族成員PCGFl蛋白抗體
xy-12070R    P2Y10G蛋白偶聯(lián)嘌呤受體p2y10抗體