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piwi樣3蛋白抗體

英文名稱 PIWIL3
中文名稱 piwi樣3蛋白抗體
別    名 HIWI3; Piwi like 3; Piwi-like protein 3; PIWIL3; PIWL3_HUMAN.
   
說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  發(fā)育生物學  干細胞  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產品應用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 101kDa
細胞定位 細胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human PIWIL3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
his gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene.

Function:
May play a role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation.

Subcellular Location:
Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis

Tissue Specificity:
Expressed in testis. xy-7612R    HIPK4同源相互作用蛋白激酶4抗體
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xy-3530R    HIRA組蛋白替換精蛋白DGGR1抗體
xy-15412R    HAPLN4透明質酸及粘蛋白4抗體
xy-11348R    Hippocalcin神經細胞特異性鈣結合蛋白抗體
xy-8507R    Hairless無毛發(fā)蛋白抗體
xy-6935R    HAND2心臟和神經嵴衍生蛋白2抗體
xy-4707R    Acetyl-Histone H4(K16)乙?；M蛋白H4(K16)抗體
xy-0750R    HLA G人類白細胞抗原G抗體（N端）
xy-0753R    HLA G人類白細胞抗原G抗體（C端）
xy-8326R    Hi95缺氧誘導基因95抗體
xy-8379R    HIP2泛素蛋白連接酶E2抗體
xy-7982R    HOXC9同源盒蛋白HOXC9抗體
xy-11630R    HCN2 + HCN4環(huán)化核苷酸調控陽離子通道蛋白亞型2/4抗體
xy-11851R    HELT轉錄因子HELT蛋白抗體
xy-11852R    HES6轉錄因子HES6抗體
xy-11853R    HMX2同源盒蛋白H6亞型2抗體
xy-11854R    HS6ST1硫酸乙酰肝素6腦苷脂轉硫酸酶1抗體
xy-11646R    Humanin神經保護肽HN抗體
xy-4646R    Capsid protein VP1大鼠細小病毒H-1株(H-1)抗體（N端）
xy-2946R    HAS1透明質酸合成酶1抗體
xy-5898R    HIF3 alpha缺氧誘導因子3α/HIF-3α抗體
xy-5899R    HIFPH4缺氧誘導因子脯氨酰4羥化酶抗體
xy-5888R    Hyaluronidase2透明質酸酶2/玻璃酸酶2抗體
xy-5822R    H Cadherin心臟鈣粘蛋白抗體
xy-6592R    HSD17B617-β-羥脫氫酶6抗體
xy-4813R    H5N1-H5禽流感H5亞型全病毒抗體
xy-2942R    ORF K14(HHV8)人類皰疹病毒8 ORF14抗體
xy-5889R    Hyaluronidase3透明質酸酶2/玻璃酸酶2抗體
xy-6538R    HOXB2同源盒蛋白B2抗體
xy-6539R    HOXB8同源盒蛋白B8抗體
xy-6540R    HSPA6熱休克蛋白70家族蛋白6抗體
xy-9913R    HGFA肝細胞生長因子激活蛋白抗體
xy-6537R    HDGF肝癌衍生生長因子抗體（高遷移率族蛋白1樣蛋白2抗體）
xy-5386R    Phospho-Histone H3(Thr3)磷酸化組蛋白H3抗體
xy-9026R    HPRT次黃嘌呤磷酸核糖基轉移酶1抗體
xy-3776R    Histone H3 (acetyl K9)乙?；M蛋白H3抗體