T-bet（T盒子轉(zhuǎn)錄因子）

T-bet（T盒子轉(zhuǎn)錄因子）

廣州健侖生物科技有限公司

T-bet表達(dá)于CD4陽(yáng)性的T淋巴細(xì)胞中。T-bet作為成熟T細(xì)胞的參考依據(jù)，在Thp中幾乎不表達(dá)，在前驅(qū)T淋巴細(xì)胞白血病中不表達(dá)。在反應(yīng)性淋巴組織如扁桃體、淋巴結(jié)和脾臟的濾泡間T細(xì)胞區(qū)的分散小淋巴細(xì)胞中T-bet表達(dá)陽(yáng)性。T-bet在B細(xì)胞淋巴增生性紊亂癥中表達(dá)，尤其是B細(xì)胞發(fā)育早期，包括前驅(qū)B細(xì)胞淋巴細(xì)胞白血病、成熟B細(xì)胞淋巴瘤、邊緣區(qū)淋巴瘤、毛細(xì)胞白血病。相反，來(lái)源于前生發(fā)中心及生發(fā)中心的B細(xì)胞淋巴瘤T-bet陰性。因此，T-bet可以作為B淋巴細(xì)胞和T淋巴細(xì)胞增生紊亂性疾病的研究及分類(lèi)標(biāo)記。

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T-bet（T盒子轉(zhuǎn)錄因子）

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

克隆號(hào)：MRQ-46

同型：IgG

適用組織：石蠟/冰凍

陽(yáng)性對(duì)照：扁桃體/毛細(xì)胞白血病

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

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【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

這個(gè)科研團(tuán)隊(duì)在研究太陽(yáng)系水冰的歷史時(shí)，重點(diǎn)關(guān)注了氫和它的重同位素氘。同位素是同一種元素的不同原子，擁有相同數(shù)目的質(zhì)子，但中子數(shù)目不同。質(zhì)量上的差異使得同位素在參與化學(xué)反應(yīng)時(shí)出現(xiàn)細(xì)微的性質(zhì)差異。因此，水分子中氫和氘的比率能夠告訴科學(xué)家，這些水分子形成時(shí)處在怎樣的環(huán)境當(dāng)中。
舉例來(lái)說(shuō)，星際空間的水冰，氘氫比率就會(huì)較高，因?yàn)樗鼈冃纬捎跇O低的溫度。但沒(méi)有人知道，在太陽(yáng)誕生的化學(xué)反應(yīng)中有多少這種富含氘的水會(huì)被破壞掉，也沒(méi)有人知道，新生太陽(yáng)系有多大的能力自己產(chǎn)生富含氘的水冰——直到現(xiàn)在。
這個(gè)研究團(tuán)隊(duì)建立了模型來(lái)模擬原行星盤(pán)，其中來(lái)自星際空間水冰中的所有氘原子都已經(jīng)被化學(xué)反應(yīng)清除了，因此這個(gè)系統(tǒng)不得不從頭開(kāi)始，在長(zhǎng)達(dá)100萬(wàn)年的模擬時(shí)間中，自行生產(chǎn)出含氘的水冰。研究團(tuán)隊(duì)之所以這樣做，是為了弄清楚這樣一個(gè)行星系統(tǒng)能不能產(chǎn)生出我們?cè)陔E石樣本、地球的海水和“時(shí)間膠囊”彗星中看到的那種氘氫比率。結(jié)果發(fā)現(xiàn)，他們的模型沒(méi)辦法做到這一點(diǎn)——這意味著，我們的太陽(yáng)系中至少有一部分水起源于星際空間，可以追溯到太陽(yáng)誕生之前。

The research team focused on hydrogen and its heavy isotope deuterium while studying the history of solar ice and water. Isotopes are different atoms of the same element, with the same number of protons, but different numbers of neutrons. The differences in quality cause subtle differences in the chemical properties of isotopes. As a result, the ratio of hydrogen to deuterium in water molecules ls scientists what environment the water molecules form when they are formed.
For example, in interslar water ice, the hydrogen-to-hydrogen ratio will be higher because they form at very low temperatures. But no one knows how much of this deuterium-depleted water will be destroyed in the chemical reaction to the birth of the sun, and no one knows how much power the nascent solar system can produce its own deuterium-rich water ice - until now.
The team created a model to simulate the protoplanetary disk in which all deuterium atoms from interslar water ice have been chemically removed, so the system has had to start over from a simulated one million years of age, Produce deuterium-containing water ice on your own. The team did this to see if such a planetary system could produce the same deuterium-hydrogen ratio we saw in meteorite samples, the Earth's seawater, and Comet of Time Capsule. The result was that their model did not do that - meaning that at least part of the water in our solar system originated in interslar space, dating back to the birth of the sun.

T-bet is expressed in CD4-positive T lymphocytes. T-bet as a reference for mature T cells, almost no expression in Thp, not expressed in prodromal T-cell leukemia. T-bet expression is positive in scattered small lymphocytes of reactive lymphoid tissue such as the tonsil, lymph nodes, and splenic interfollicular T-cell regions. T-bet is expressed in B-cell lymphoproliferative disorders, especially in the early stages of B cell development, including primed B-cell lymphocytic leukemia, mature B-cell lymphoma, marginal zone lymphoma, and hairy cell leukemia. In contrast, B-cell lymphoma derived from pre-germinal centers and germinal centers is negative for T-bet. Therefore, T-bet can be used as B lymphocytes and T lymphocyte dysplasia research and classification of markers.