細(xì)胞壓力儀應(yīng)用文獻(xiàn)

品牌美國flexcell ，型號(hào)：FX-5000C

美國Flexcell公司專注于細(xì)胞組織應(yīng)力（牽張拉伸應(yīng)力、三維水凝膠牽張拉伸應(yīng)力、壓應(yīng)力和流體切應(yīng)力等）加載刺激培養(yǎng)產(chǎn)品的設(shè)計(jì)和制造，提供*的體外細(xì)胞拉應(yīng)力、壓應(yīng)力和流體剪切應(yīng)力加載刺激與立體水凝膠支架三維細(xì)胞組織牽拉加載培養(yǎng)系統(tǒng)而*。其產(chǎn)品成熟度高、成功應(yīng)用文獻(xiàn)量達(dá)4000多篇，國內(nèi)有包括上海交通大學(xué)、復(fù)旦大學(xué)、同濟(jì)大學(xué)、上海第九醫(yī)院、中科院力學(xué)所、北京大學(xué)第三醫(yī)院、北航生物與醫(yī)學(xué)工程學(xué)院、都醫(yī)科大學(xué)、廣州醫(yī)科大學(xué)、南方科技大學(xué)、福建協(xié)和醫(yī)院、南方醫(yī)科大學(xué)近100家成功高校、醫(yī)院及基礎(chǔ)科研單位使用，無技術(shù)風(fēng)險(xiǎn)和使用風(fēng)險(xiǎn)，flexcell體外高通量細(xì)胞牽張拉伸力、壓應(yīng)力以及流體剪切力加載培養(yǎng)系統(tǒng)已成為細(xì)胞力學(xué)體外加載模型的黃金標(biāo)準(zhǔn)，是細(xì)胞組織力學(xué)研究者的shou選。

 FX-5000C細(xì)胞壓力加載培養(yǎng)與實(shí)時(shí)觀察系統(tǒng)(flexcell FX5000 Compression system)現(xiàn)貨銷售，介紹如下：

FX-5000C對(duì)各種組織，三維細(xì)胞培養(yǎng)物提供壓力加載
計(jì)算機(jī)控制的壓力加載系統(tǒng)，對(duì)各種組織，三維細(xì)胞培養(yǎng)物提供周期性的或靜態(tài)的壓力加載
夾在活塞和固定臺(tái)之間的BioPress細(xì)胞培養(yǎng)板可承受正壓力的大值為14磅，小值為0.1磅。
檢測(cè)各種組織和細(xì)胞在壓力作用下的生物化學(xué)反應(yīng)，例如：軟骨組織，椎間盤骨組織，肌腱組織，韌帶組織，以及從肌肉，肺，心臟，血管，皮膚，肌腱，韌帶，軟骨和骨中分離出來的細(xì)胞。
在主機(jī)的控制下，壓力傳導(dǎo)儀內(nèi)的密封閥門裝置自動(dòng)調(diào)節(jié)和控制壓力。
活塞和固定臺(tái)在BioPress細(xì)胞培養(yǎng)板或者StagePresser顯微儀器上擠壓樣品。
同一程序中可以同時(shí)運(yùn)行多種頻率，多種振幅和多種波形
同時(shí)兼容四個(gè)獨(dú)立的FlexLink壓力加載和/或應(yīng)力加載傳導(dǎo)儀。
更好地控制在超低或超高壓力下的波形。
頻率在0.01- 5 Hz。
多種波形種類：
靜態(tài)波形
正旋波形
心動(dòng)波形
三角波形
矩形波形
各種特制波形

細(xì)胞壓力實(shí)驗(yàn)裝置應(yīng)用文獻(xiàn)：

[1] Baccam A, Benoni-Sviercovich A, Rocchi M, Moresi V, Seelaender M, Li Z, et al. The Mechanical Stimulation of Myotubes Counteracts the Effects of Tumor-Derived Factors Through the Modulation of the Activin/Follistatin Ratio. Frontiers in physiology. 2019;10:401.
[2] Bhattacharya MR, Bautista DM, Wu K, Haeberle H, Lumpkin EA, Julius D. Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proceedings of the National Academy of Sciences of the United States of America. 2008;105:20015-20.
[3] Bianchi F, George JH, Malboubi M, Jerusalem A, Thompson MS, Ye H. Engineering a uniaxial substrate-stretching device for simultaneous electrophysiological measurements and imaging of strained peripheral neurons. Medical engineering & physics. 2019;67:1-10.
[4] Boyle ST, Kular J, Nobis M, Ruszkiewicz A, Timpson P, Samuel MS. Acute compressive stress activates RHO/ROCK-mediated cellular processes. Small GTPases. 2018:1-17.
[5] Dolzani P, Assirelli E, Pulsatelli L, Meliconi R, Mariani E, Neri S. Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components. PloS one. 2019;14:e0222947.
[6] Fang B, Liu Y, Zheng D, Shan S, Wang C, Gao Y, et al. The effects of mechanical stretch on the biological characteristics of human adipose-derived stem cells. Journal of cellular and molecular medicine. 2019;23:4244-55.
[7] Friedrich O, Merten AL, Schneidereit D, Guo Y, Schurmann S, Martinac B. Stretch in Focus: 2D Inplane Cell Stretch Systems for Studies of Cardiac Mechano-Signaling. Frontiers in bioengineering and biotechnology. 2019;7:55.
[8] He YB, Liu SY, Deng SY, Kuang LP, Xu SY, Li Z, et al. Mechanical Stretch Promotes the Osteogenic Differentiation of Bone Mesenchymal Stem Cells Induced by Erythropoietin. Stem cells international. 2019;2019:1839627.
[9] Hilscher MB, Sehrawat T, Arab JP, Zeng Z, Gao J, Liu M, et al. Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension. Gastroenterology. 2019;157:193-209 e9.
[10] Kanzaki H, Wada S, Yamaguchi Y, Katsumata Y, Itohiya K, Fukaya S, et al. Compression and tension variably alter Osteoprotegerin expression via miR-3198 in periodontal ligament cells. BMC molecular and cell biology. 2019;20:6.
[11] Klymenko Y, Wates RB, Weiss-Bilka H, Lombard R, Liu Y, Campbell L, et al. Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates. Disease models & mechanisms. 2018;11.
[12] Liang X, Wang Z, Gao M, Wu S, Zhang J, Liu Q, et al. Cyclic stretch induced oxidative stress by mitochondrial and NADPH oxidase in retinal pigment epithelial cells. BMC ophthalmology. 2019;19:79.
[13] Liu Y, Huang X, Yu H, Yang J, Li Y, Yuan X, et al. HIF-1alpha-TWIST pathway restrains cyclic mechanical stretch-induced osteogenic differentiation of bone marrow mesenchymal stem cells. Connective tissue research. 2019;60:544-54.
[14] Matheson LA, Fairbank NJ, Maksym GN, Paul Santerre J, Labow RS. Characterization of the Flexcell Uniflex cyclic strain culture system with U937 macrophage-like cells. Biomaterials. 2006;27:226-33.
[15] Spassov SG, Kessler C, Jost R, Schumann S. Ventilation-Like Mechanical Strain Modulates the Inflammatory Response of BEAS2B Epithelial Cells. Oxidative medicine and cellular longevity. 2019;2019:2769761.
[16] van Kelle MAJ, Khalil N, Foolen J, Loerakker S, Bouten CVC. Increased Cell Traction-Induced Prestress in Dynamically Cultured Microtissues. Frontiers in bioengineering and biotechnology. 2019;7:41.
[17] Zhang J, Xu S, Zhang Y, Zou S, Li X. Effects of equibiaxial mechanical stretch on extracellular matrix-related gene expression in human calvarial osteoblasts. European journal of oral sciences. 2019;127:10-8.