Clickchemistrytools/Vectorlabs現(xiàn)貨Ac4ManNAz貨號(hào)1086-25

時(shí)間：2024-3-13閱讀：772

The unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier. Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis. PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Ac4GalNAz 是一種屬于 alkyl chain 類的 PROTAC linker，可用于 PROTAC 分子的合成。

靶點(diǎn)科技現(xiàn)貨N-azidoacetylgalactosamine-tetraacylated (Ac4GalNAz) (CCT-1086)

精選文獻(xiàn)Selected References

1.Simon P. Wisnovsky, et al. (2020). Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation. PNAS, 117 (41), 25293-25301.

2.Ranzinger, R., et al. (2020). Mass Spectrometric Method for the Unambiguous Profiling of Cellular Dynamic Glycosylation. ACS Chem. Biol., 15, 10, 2692-2701.

3.Suttapitugsakul, S., et al. (2019). Surface Glycoproteomic Analysis Reveals That Both Unique and Differential Expression of Surface Glycoproteins Determine the Cell Type. Anal. Chem., 91(10), 6934–42.

生物活性

Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl-Chain

體外研究
(In Vitro)

PROTAC 包含兩個(gè)不同的配體，通過一個(gè)接頭連接；一個(gè)是 E3 泛素連接酶的配體，另一個(gè)是靶蛋白的配體。PROTAC 利用細(xì)胞內(nèi)泛素-蛋白酶體系統(tǒng)選擇性降解靶蛋白^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

430.37

Formula

C₁₆H₂₂N₄O₁₀

CAS 號(hào)

653600-56-7

性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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靶點(diǎn)科技（北京）有限公司

Clickchemistrytools/Vectorlabs現(xiàn)貨Ac4ManNAz貨號(hào)1086-25

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