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Molecular Targeting Technologies熒光素CY5偶聯(lián)Duramycin產(chǎn)品說明書

時(shí)間:2025-1-10閱讀:113

Molecular Targeting Technologies國(guó)內(nèi)代理Target Technology。Duramycin (Moli1901) 是一種來源于 Streptomyces cinnamoneuma 的羊毛硫細(xì)菌素。Duramycin 也是一種抗菌肽。Duramycin 可用于囊性纖維化(CF)的研究。熒光素CY5偶聯(lián)Duramycin:Duramycin-Cy5 Fluorescent Conjugate(貨號(hào):D-1002),通過偶聯(lián)熒光素,我們可以流式或者免疫熒光檢測(cè)。甚至可以動(dòng)態(tài)監(jiān)測(cè)。


生物活性

Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF).

體內(nèi)研究
(In Vivo)

Evaluation of [68Ga]NODAGA-Duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. Organ uptake is analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [68Ga]NODAGA-Duramycin. [68Ga]NODAGA-Duramycin PET/CT is successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice.

These methods are for reference only.

Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT00671736AOP Orphan Pharmaceuticals AG
Cystic Fibrosis
October 2007Phase 2
分子量

2013.28

Formula

C89H125N23O25S3

CAS 號(hào)

1391-36-2

性狀

固體

外觀顏色

White to off-white

Sequence

Cys-Lys-Gln-Cys-Cys-Ala-Phe-Gly-Pro-Phe-{Abu}-Phe-Val-Cys-Asp-Gly-Asn-{Abu}-Lys-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11)








Product Description:

A Cy5 dye is attached to amino groups of duramycin. The conjugate contains 1 Cy5 dye molecule per duramycin molecule.  Duramycin binds phosphatidylethanolamine (PE) at a 1:1 ratio with high affinity (Kd of 4-6 nM) and exclusive specificity.   Properties of Duramycin-Cy5 。

Molecular Targeting Technologies熒光素CY5偶聯(lián)Duramycin產(chǎn)品說明書

Molecular Targeting Technologies熒光素CY5偶聯(lián)Duramycin產(chǎn)品說明書

產(chǎn)品名稱:Duramycin-Cy5 Fluorescent Conjugate

貨號(hào):D-1002

規(guī)格:132ugrams

代理:Targeting Technology(靶點(diǎn)科技)

溶解方法:

向小瓶中加入200uL 1%DMSO水溶液,用移液器上下吸液以溶解固體,得到就是250uM的含1%DMSO的水溶液。



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