MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào),我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。
MCE 國(guó)際站:JC-1
品牌:MedChemExpress (MCE)
貨號(hào):HY-15534
CAS:3520-43-2
Synonyms:CBIC2
純度:0.9804
存儲(chǔ)條件:4°C,密封保存,避光防潮 *溶劑中:-80°C,6個(gè)月;-20°C,1個(gè)月(密封保存,避光防潮)
運(yùn)輸條件:美國(guó)大陸的室溫;其他地方可能有所不同。
產(chǎn)品活性:JC-1 (CBIC2) 是一種廣泛用于檢測(cè)線粒體膜電位的理想熒光探針。JC-1 染料以電勢(shì)依賴性的方式積聚在線粒體內(nèi),可以用來(lái)檢測(cè)細(xì)胞、組織或純化的線粒體膜電位。正常線粒體內(nèi),JC-1 聚集在線粒體基質(zhì)中形成聚合物,聚合物發(fā)出強(qiáng)烈的紅色熒光 (Ex=488 nm, Em=595 nm) ;在線粒體膜電位較低時(shí),JC-1不能聚集在線粒體的基質(zhì)中,產(chǎn)生綠色熒光 (Ex=488 nm, Em=530 nm) 。
Emission (Em):527/590
Excitation (Ex):490
熱銷產(chǎn)品:Amivantamab | Temozolomide | Aldosterone | Mirvetuximab soravtansine | Pexidartinib | Prostaglandin E2 | Pembrolizumab | DAPT | Pilocarpine (Hydrochloride) | Ibrutinib
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
參考文獻(xiàn):
[1]. A Perelman, et al. JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry. Cell Death Dis. 2012 Nov 22;3:e430.
[2]. Vera C. Keil, et al. Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria. Pflügers Archiv - European Journal of Physiology. 2011,462(5): 693-708.
[3]. Jung-Ho LEE, et al. Real-time analysis of amyloid fibril formation of α-synuclein using a fibrillation-state-specific fluorescent probe of JC-1. Biochem. J. 2009, 418:311-323.
[4]. Salvioli S, et al. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 1997 Jul 7;411(1):77-82.
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