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ACY-1083

CAS No. : 1708113-43-2

產(chǎn)品活性：ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor with an IC₅₀ of 3 nM and is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶點(diǎn)：HDAC

In Vitro: Treatment with ACY-1083 (30 and 300 nM) significantly improves cell viability in a dose-dependent manner.

In Vivo: ACY-1083 (i.p.; 10 mg/kg; for 7 days) effectively relieves Cisplatin-induced mechanical allodynia in C57BL/6J mice
ACY-1083 (oral doses of 3 mg/kg ACY-1083 for 7 days) reverses Paclitaxel-induced mechanical allodynia in adult male SD rats.
Mice dosed with 5 mg/kg ACY-1083 by intraperitoneal (i.p.) injection have a maximum plasma concentration (C_max) of 936 ng/mL, a half-life (T_1/2) of 3.5 hours, and a biologically active plasma exposure of 8 hours after dosing.

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