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Budesonide

CAS No. : 51333-22-3

產(chǎn)品活性：Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma.

研究領(lǐng)域：Immunology/Inflammation  |  Vitamin D Related/Nuclear Receptor

作用靶點(diǎn)：Glucocorticoid Receptor

In Vitro: Budesonide is selective for human glucocorticoid receptor (hGR; EC₅₀=45.7 pM) over mineralocorticoid receptors (EC₅₀=7,620 pM) in CV-1 cells.
Budesonide (30?min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100?ng/mL) plus ATP (5?mM) in macrophages (RAW 264.7 cells).

In Vivo: Budesonide (2.0 mg/kg; orally via their diet; at 2, 7 and 21 days prior to killing) decreases the size of lung tumors.
Budesonide (0.5?mg/kg; intranasal administration 1?h before LPS injection (5?mg/kg)) pretreatment dramatically attenuates pathological injury and reduces pathological scores in mice with ALI in adult male C57BL/6 mice.

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