MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務。

Rupatadine

CAS No. : 158876-82-5

產(chǎn)品活性：Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with K_is of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria.

研究領域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation  |  Autophagy

作用靶點：Histamine Receptor  |  Autophagy

In Vitro: Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA₂=9.29) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4).
Rupatadine competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA₂=6.68) and in human platelet-rich plasma (HPRP) (IC₅₀=0.68 μM), while not affecting ADP- or arachidonic acid-induced platelet aggregation.
Rupatadine (0.1-30 μM) inhibits TNF-α secretion in a concentration-dependent manner, with maximum values of 92.5%.

In Vivo: Rupatadine blocks histamine- and PAF-induced effects in vivo, such as hypotension in rats (ID₅₀=1.4 and 0.44 mg/kg i.v., respectively) and bronchoconstriction in guinea pigs (ID₅₀=113 and 9.6 μg/kg i.v.).
Rupatadine potently inhibits PAF-induced mortality in mice (ID₅₀=0.31 and 3.0 mg/kg i.v. and p.o., respectively) and endotoxin-induced mortality in mice and rats (ID₅₀=1.6 and 0.66 mg/kg i.v.).
Rupatadine (6 mg/kg) promotes the absorption of the lesions and decreased the density of lungs.

相關產(chǎn)品：Perphenazine-d₈ (dihydrochloride)  |  Zotepine  |  Emedastine difumarate  |  Cipralisant (enantiomer)  |  Doxepin-d₃ (hydrochloride)  |  ST-1006  |  Chlorphenoxamine  |  Clemastine-d₅ (fumarate)  |  H3 receptor-MO-1  |  Izuforant  |  ABT-239  |  Fexofenadine  |  Ketotifen fumarate  |  S 38093  |  Roxatidine  |  Histamine phosphate  |  Ciproxifan maleate  |  LML134  |  Olopatadine-d₃ (hydrochloride)  |  JNJ10191584 maleate  |  (Z)-Olopatadine-d₃ (hydrochloride)  |  Cetirizine  |  Cinitapride  |  Diphenylpyraline hydrochloride  |  Doxylamine-d₅  |  Cyclizine lactate  |  FRG8701  |  Methdilazine hydrochloride  |  Azelastine hydrochloride  |  Brompheniramine maleate

熱門產(chǎn)品線：重組蛋白  |  化合物庫  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標記物  |  寡核苷酸  |  抗體  |  點擊化學

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介紹:
•   MCE (MedChemExpress) 擁有200 多種全球僅有化合物庫，我們致力于為全球科研客戶提供前沿的高品質(zhì)小分子活性化合物；
•   50,000 多種高選擇性抑制劑、激動劑涉及各熱門信號通路及疾病領；
•   產(chǎn)品種類涵蓋各種重組蛋白，多肽，常用試劑盒 ，更有 PROTAC、ADC 等特色產(chǎn)品，廣泛應用于新藥研發(fā)、生命科學等科研項目；
•   提供虛擬篩選，離子通道篩選，代謝組學分析檢測分析，藥物篩選等專業(yè)技術服務；
•   設有專業(yè)的實驗中心和嚴格的質(zhì)控、驗證體系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各項質(zhì)檢報告，確保產(chǎn)品的高純度、高品質(zhì)；
•   產(chǎn)品的生物活性多經(jīng)各國客戶實驗驗證；
•   Nature, Cell, Science 等多種頂級期刊及制藥 Patent 收錄了MCE客戶的科研成果；
•   專業(yè)團隊跟蹤最新的制藥及生命科學研究進展，為您提供全球新的活性化合物；
•   與世界各大制藥公司及著名科研機構建立了長期的合作。