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SAG

CAS No. : 912545-86-9

產(chǎn)品活性：SAG is a potent Smoothened (Smo) receptor agonist (EC₅₀=3 nM; K_d=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.

研究領(lǐng)域：Stem Cell/Wnt

作用靶點：Smo

In Vitro: SAG (0.1 nM-100 μM; 30 h) induces firefly luciferase expression in Shh-LIGHT2 cells with an EC₅₀ of 3 nM and then inhibits expression at higher concentrations.
SAG (1-1000 nM; 1 h) competes for the binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells, yielding an apparent dissociation constant (K_d) of 59 nM for the SAG/Smo complex.
SAG (100 nM) inhibits the inhibitory effect of ShhN-induced pathway activation by Robotnikinin.
SAG (250 nM; 48 h) significantly increases SMO mRNA and protein expression in MDAMB231 cells.
SAG (250 nM; 24 and 48 h) increases CAXII mRNA expression in MDAMB231 cells at 24h in normoxic and hypoxic conditions in MDAMB231 cells.
SAG (250 nM; 24 h) increases MDAMB231 cells migration.

In Vivo: SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice.
SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice.

相關(guān)產(chǎn)品：Bioactive Compound Library Plus  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Targeted Diversity Library  |  Heterocyclic Compound Library  |  Purmorphamine (GMP)  |  IHR-1  |  Sonidegib  |  Saikosaponin B1  |  LEQ506  |  RL-0070933  |  ALLO-2  |  GSA-10  |  Cyclopamine  |  SMO-IN-3  |  Saridegib  |  PF-5274857  |  TPB15  |  BMS-833923  |  MRT-83  |  SANT-1  |  IHR-Cy3  |  SMO-IN-2  |  SAG hydrochloride  |  20(S)-Hydroxycholesterol  |  Fluticasone  |  MK-4101  |  AZD7254  |  MRT-14  |  DY131  |  Halcinonide  |  MRT-81

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