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Daprodustat

CAS No. : 960539-70-2

產品活性：Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

研究領域：Metabolic Enzyme/Protease

作用靶點：HIF/HIF Prolyl-Hydroxylase

In Vitro: GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers.

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