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DG172 dihydrochloride

CAS No. : 1361504-77-9

產(chǎn)品活性：DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC₅₀ of 27 nM.

研究領(lǐng)域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor

作用靶點(diǎn)：PPAR

In Vitro: DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC₅₀ of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC₅₀, 9.5 nM). DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b⁺/Gr1⁺ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells.

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